Integrative computational evaluation of genetic markers for Alzheimer’s disease
المؤلفون المشاركون
Li, Tao
Li, Zhe
Manor, Lydia C.
Xiong, ZhenZhen
Cao, Hongbao
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 5 (31 يوليو/تموز 2018)، ص ص. 996-1002، 7ص.
الناشر
تاريخ النشر
2018-07-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Recent studies have reported hundreds of genes linked to Alzheimer’s Disease (AD).
However, many of these candidate genes may be not identified in different studies when analyses were replicated.
Moreover, results could be controversial.
Here, we proposed a computational workflow to curate and evaluate AD related genes.
The method integrates large scale literature knowledge data and gene expression data that were acquired from postmortem human brain regions (AD case/control: 31/32 and 22/8).
Pathway Enrichment, Sub-Network Enrichment, and Gene-Gene Interaction analysis were conducted to study the pathogenic profile of the candidate genes, with 4 metrics proposed and validated for each gene.
By using our approach, a scalable AD genetic database was developed, including AD related genes, pathways, diseases and info of supporting references.
The AD case/control classification supported the effectiveness of the 4 proposed metrics, which successfully identified 21 well-studied AD genes (i.g.
TGFB1, CTNNB1, APP, IL1B, PSEN1, PTGS2, IL6, VEGFA, SOD1, AKT1, CDK5, TNF, GSK3B, TP53, CCL2, BDNF, NGF, IGF1, SIRT1, AGER and TLR) and highlighted one recently reported AD gene (i.g.
ITGB1).
The computational biology approach and the AD database developed in this study provide a valuable resource which may facilitate the understanding of the AD genetic profile.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Zhe& Xiong, ZhenZhen& Manor, Lydia C.& Cao, Hongbao& Li, Tao. 2018. Integrative computational evaluation of genetic markers for Alzheimer’s disease. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.996-1002.
https://search.emarefa.net/detail/BIM-838470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiong, ZhenZhen…[et al.]. Integrative computational evaluation of genetic markers for Alzheimer’s disease. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.996-1002.
https://search.emarefa.net/detail/BIM-838470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Zhe& Xiong, ZhenZhen& Manor, Lydia C.& Cao, Hongbao& Li, Tao. Integrative computational evaluation of genetic markers for Alzheimer’s disease. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.996-1002.
https://search.emarefa.net/detail/BIM-838470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1002
رقم السجل
BIM-838470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر