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Integrative computational evaluation of genetic markers for Alzheimer’s disease
Joint Authors
Li, Tao
Li, Zhe
Manor, Lydia C.
Xiong, ZhenZhen
Cao, Hongbao
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 5 (31 Jul. 2018), pp.996-1002, 7 p.
Publisher
Publication Date
2018-07-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Recent studies have reported hundreds of genes linked to Alzheimer’s Disease (AD).
However, many of these candidate genes may be not identified in different studies when analyses were replicated.
Moreover, results could be controversial.
Here, we proposed a computational workflow to curate and evaluate AD related genes.
The method integrates large scale literature knowledge data and gene expression data that were acquired from postmortem human brain regions (AD case/control: 31/32 and 22/8).
Pathway Enrichment, Sub-Network Enrichment, and Gene-Gene Interaction analysis were conducted to study the pathogenic profile of the candidate genes, with 4 metrics proposed and validated for each gene.
By using our approach, a scalable AD genetic database was developed, including AD related genes, pathways, diseases and info of supporting references.
The AD case/control classification supported the effectiveness of the 4 proposed metrics, which successfully identified 21 well-studied AD genes (i.g.
TGFB1, CTNNB1, APP, IL1B, PSEN1, PTGS2, IL6, VEGFA, SOD1, AKT1, CDK5, TNF, GSK3B, TP53, CCL2, BDNF, NGF, IGF1, SIRT1, AGER and TLR) and highlighted one recently reported AD gene (i.g.
ITGB1).
The computational biology approach and the AD database developed in this study provide a valuable resource which may facilitate the understanding of the AD genetic profile.
American Psychological Association (APA)
Li, Zhe& Xiong, ZhenZhen& Manor, Lydia C.& Cao, Hongbao& Li, Tao. 2018. Integrative computational evaluation of genetic markers for Alzheimer’s disease. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.996-1002.
https://search.emarefa.net/detail/BIM-838470
Modern Language Association (MLA)
Xiong, ZhenZhen…[et al.]. Integrative computational evaluation of genetic markers for Alzheimer’s disease. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.996-1002.
https://search.emarefa.net/detail/BIM-838470
American Medical Association (AMA)
Li, Zhe& Xiong, ZhenZhen& Manor, Lydia C.& Cao, Hongbao& Li, Tao. Integrative computational evaluation of genetic markers for Alzheimer’s disease. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.996-1002.
https://search.emarefa.net/detail/BIM-838470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1002
Record ID
BIM-838470