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MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9
المؤلفون المشاركون
Ma, Xiaoping
Shi, Wentian
Peng, Lina
Qin, Xuying
Hui, Yuzuo
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 5 (31 يوليو/تموز 2018)، ص ص. 863-867، 5ص.
الناشر
تاريخ النشر
2018-07-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Up to date, the cervical cancer remains to be one of the leading gynecological malignancies worldwide.
MicroRNAs (miRNAs) play critical roles in the process of tumor initiation and progression.
However, miR-96 has rarely been investigated in human cervical carcinoma.
We aimed to investigate the biological function and underlying molecular mechanism of miR-96 in human cervical carcinoma.
MiR-96 levels were determined by qRT-PCR.
Protein tyrosine phosphatase, non-receptor type 9 (PTPN9) mRNA and protein levels were investigated by qRT-PCR and western blotting.
The cellular proliferation in cervical cells was monitored by CyQuant assay.
Soft agar assay was employed to determine the tumorigenicity.
30 UTR luciferase assay was used to validate the target gene of miR-96.
SPSS was used to analyze statistical significance in different treatment.
MiR-96 was dramatically upregulated in human cervical tumor tissues.
Overexpression of miR-96 was found to significantly promote the cellular proliferation and tumorigenicity of cervical cells.
Furthermore, we showed that PTPN9 was a direct target gene of miR-96 and had opposite effect to those of miR-96 on cervical cells.
MiR-96 may promote the cellular proliferation and tumorigenicity of cervical cells by silencing PTPN9.
Our study highlights an importantly regulatory role of miR-96 and suggests that an appropriate manipulation of miR-96 may be a new treatment of human cervical carcinoma in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Xiaoping& Shi, Wentian& Peng, Lina& Qin, Xuying& Hui, Yuzuo. 2018. MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.863-867.
https://search.emarefa.net/detail/BIM-838474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Wentian…[et al.]. MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.863-867.
https://search.emarefa.net/detail/BIM-838474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Xiaoping& Shi, Wentian& Peng, Lina& Qin, Xuying& Hui, Yuzuo. MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.863-867.
https://search.emarefa.net/detail/BIM-838474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 867
رقم السجل
BIM-838474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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