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Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review
المؤلفون المشاركون
Zhang, Qi
Yang, Dexiang
Dai, Ranran
Fang, Ping
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 5 (31 يوليو/تموز 2018)، ص ص. 888-894، 7ص.
الناشر
تاريخ النشر
2018-07-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Although many strategies have been developed for non-small cell lung cancer (NSCLC), more secondary and further treatments are needed due to drug resistance or tumor recurrence.
Apatinib is a novel oral antiangiogenic agent and in this study, we aim to investigate the clinical value of apatinib in heavily pretreated NSCLC.
Here, we reported the characteristics, efficacy and adverse events of three patients treated with apatinib (500 mg/day).
We also summarized the currently available evidence and ongoing clinical trials regarding the use of apatinib in NSCLC.
Two cases of adenocarcinoma and one case of squamous cell carcinoma were treated with apatinib due to disease progression after previous treatments of chemotherapy and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI).
All patients responded to apatinib rapidly and underwent drug resistance shortly afterwards.
The patient with squamous cell carcinoma died of hemoptysis.
Other adverse events were acceptable.
All previous relevant studies were compared and showed similar results but a longer progression-free survival.
Additionally, ongoing clinical trials were systematically searched and listed.
In conclusion, apatinib shows some efficacy in heavily treated NSCLC and generally tolerable toxicity in non-squamous NSCLC.
More solid evidence will be accessible in near future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Dexiang& Dai, Ranran& Zhang, Qi& Fang, Ping. 2018. Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.888-894.
https://search.emarefa.net/detail/BIM-838486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dai, Ranran…[et al.]. Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.888-894.
https://search.emarefa.net/detail/BIM-838486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Dexiang& Dai, Ranran& Zhang, Qi& Fang, Ping. Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.888-894.
https://search.emarefa.net/detail/BIM-838486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 894
رقم السجل
BIM-838486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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