Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review
Joint Authors
Zhang, Qi
Yang, Dexiang
Dai, Ranran
Fang, Ping
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 5 (31 Jul. 2018), pp.888-894, 7 p.
Publisher
Publication Date
2018-07-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Although many strategies have been developed for non-small cell lung cancer (NSCLC), more secondary and further treatments are needed due to drug resistance or tumor recurrence.
Apatinib is a novel oral antiangiogenic agent and in this study, we aim to investigate the clinical value of apatinib in heavily pretreated NSCLC.
Here, we reported the characteristics, efficacy and adverse events of three patients treated with apatinib (500 mg/day).
We also summarized the currently available evidence and ongoing clinical trials regarding the use of apatinib in NSCLC.
Two cases of adenocarcinoma and one case of squamous cell carcinoma were treated with apatinib due to disease progression after previous treatments of chemotherapy and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI).
All patients responded to apatinib rapidly and underwent drug resistance shortly afterwards.
The patient with squamous cell carcinoma died of hemoptysis.
Other adverse events were acceptable.
All previous relevant studies were compared and showed similar results but a longer progression-free survival.
Additionally, ongoing clinical trials were systematically searched and listed.
In conclusion, apatinib shows some efficacy in heavily treated NSCLC and generally tolerable toxicity in non-squamous NSCLC.
More solid evidence will be accessible in near future.
American Psychological Association (APA)
Yang, Dexiang& Dai, Ranran& Zhang, Qi& Fang, Ping. 2018. Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.888-894.
https://search.emarefa.net/detail/BIM-838486
Modern Language Association (MLA)
Dai, Ranran…[et al.]. Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.888-894.
https://search.emarefa.net/detail/BIM-838486
American Medical Association (AMA)
Yang, Dexiang& Dai, Ranran& Zhang, Qi& Fang, Ping. Apatinib for heavily treated patients with non-small cell lung cancer : report of a case series and literature review. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.888-894.
https://search.emarefa.net/detail/BIM-838486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 894
Record ID
BIM-838486