Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations
المؤلفون المشاركون
Cosentino, James
Cheema, Anmol
Kalathil, Sheila
Bajwa, Ravneet
Costanzo, Eric J.
Cheng, Jennifer
Vachharajani, Tushar
Asyf, Arif
Husayn, Muhammad A.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 29، العدد 2 (30 إبريل/نيسان 2018)، ص ص. 276-283، 8ص.
الناشر
تاريخ النشر
2018-04-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and widespread damage to multiple organs including the kidney.
The syndrome has a high mortality necessitating the need for an early diagnosis to limit target organ damage.
Because thrombotic microangiopathies present with similar clinical picture, accurate diagnosis of aHUS continues to pose a diagnostic challenge.
This article focuses on the role of four distinct aspects of aHUS that assist clinicians in making an accurate diagnosis of aHUS.
First, because of the lack of a single specific laboratory test for aHUS, other forms of thrombotic microangiopathies such as thrombotic thrombocytopenic purpura and Shiga toxin-associated HUS must be excluded to successfully establish the diagnosis of aHUS.
Second, application of the knowledge of complement-amplifying conditions is critically important in making an accurate diagnosis.
Third, when available, a renal biopsy can reveal changes consistent with thrombotic microangiopathy.
Fourth, genetic mutations are increasingly clarifying the underlying complement dysfunction and gaining importance in the diagnosis and management of patients with aHUS.
This review concentrates on the four aspects of aHUS and calls for heightened awareness in making an accurate diagnosis of aHUS
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Husayn, Muhammad A.& Cheema, Anmol& Kalathil, Sheila& Bajwa, Ravneet& Costanzo, Eric J.& Cosentino, James…[et al.]. 2018. Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 2, pp.276-283.
https://search.emarefa.net/detail/BIM-838504
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Husayn, Muhammad A.…[et al.]. Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 2 (Mar. / Apr. 2018), pp.276-283.
https://search.emarefa.net/detail/BIM-838504
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Husayn, Muhammad A.& Cheema, Anmol& Kalathil, Sheila& Bajwa, Ravneet& Costanzo, Eric J.& Cosentino, James…[et al.]. Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 2, pp.276-283.
https://search.emarefa.net/detail/BIM-838504
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 281-283
رقم السجل
BIM-838504
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر