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Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations
Joint Authors
Cosentino, James
Cheema, Anmol
Kalathil, Sheila
Bajwa, Ravneet
Costanzo, Eric J.
Cheng, Jennifer
Vachharajani, Tushar
Asyf, Arif
Husayn, Muhammad A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 2 (30 Apr. 2018), pp.276-283, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-04-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and widespread damage to multiple organs including the kidney.
The syndrome has a high mortality necessitating the need for an early diagnosis to limit target organ damage.
Because thrombotic microangiopathies present with similar clinical picture, accurate diagnosis of aHUS continues to pose a diagnostic challenge.
This article focuses on the role of four distinct aspects of aHUS that assist clinicians in making an accurate diagnosis of aHUS.
First, because of the lack of a single specific laboratory test for aHUS, other forms of thrombotic microangiopathies such as thrombotic thrombocytopenic purpura and Shiga toxin-associated HUS must be excluded to successfully establish the diagnosis of aHUS.
Second, application of the knowledge of complement-amplifying conditions is critically important in making an accurate diagnosis.
Third, when available, a renal biopsy can reveal changes consistent with thrombotic microangiopathy.
Fourth, genetic mutations are increasingly clarifying the underlying complement dysfunction and gaining importance in the diagnosis and management of patients with aHUS.
This review concentrates on the four aspects of aHUS and calls for heightened awareness in making an accurate diagnosis of aHUS
American Psychological Association (APA)
Husayn, Muhammad A.& Cheema, Anmol& Kalathil, Sheila& Bajwa, Ravneet& Costanzo, Eric J.& Asyf, Arif…[et al.]. 2018. Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 2, pp.276-283.
https://search.emarefa.net/detail/BIM-838504
Modern Language Association (MLA)
Asyf, Arif…[et al.]. Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 2 (Mar. / Apr. 2018), pp.276-283.
https://search.emarefa.net/detail/BIM-838504
American Medical Association (AMA)
Husayn, Muhammad A.& Cheema, Anmol& Kalathil, Sheila& Bajwa, Ravneet& Costanzo, Eric J.& Asyf, Arif…[et al.]. Atypical hemolytic uremic syndrome : laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 2, pp.276-283.
https://search.emarefa.net/detail/BIM-838504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 281-283
Record ID
BIM-838504