Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives
المؤلفون المشاركون
Kubbah, Ammar Abd al-Razzaq Mahmud
Abd al-Rahim, Nida Abd al-Hamid
المصدر
Iraqi Journal of Pharmaceutical Sciences
العدد
المجلد 27، العدد 1 (30 يونيو/حزيران 2018)، ص ص. 79-88، 10ص.
الناشر
تاريخ النشر
2018-06-30
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
2-amino-4-(4-chloro phenyl)-1,3-thiazole (1) was synthesized by refluxing thiourea with para-chloro phenacyl bromide in absolute methanol.
The condensation of amine compound (1) with phenylisothiocyanate in the presence of pyridine will produce 1-(4-(4-chlorophenyl)thiazol-2-yl)-3-phenylthiourea(2), which is upon treatment with 2,4 dinitrophenyl hydrazine by conventional method, afforded 1- ( 4 - ( 4 – chlorophenyl ) thiazol – 2 – yl ) – 3 - phenylhydrazonamide,N' - ( 2 , 4 -dinitrophenyl) ,(3).The characterization of the titled compounds were performed utilizing FTIR spectroscopy, 1HNMR and CHNS elemental analysis, and by measurements of their physical properties.
The synthesized compounds had been screened for their, in vitro preliminary antimicrobial activity against three Gram-positive bacteria: (Staph.
aureus, Micrococcus luteus and Bacillus subtilis) and three Gram-negative bacteria : (Pseud.aeruginosa, E.coli and Proteus mirabilis) ,and two fungal strains(Candida albicans and Candida glabrata ), using a minimum inhibitory concentration (MIC) of 100 µgml of test compound, by well diffusion method.
The derivatives showed moderate antibacterial activity against Gram-positive Staphylococcus aureus and Bacillus subtilis & high antifungal activity against Candida glabrata and Candida albicans.
Computational study was performed to calculate some of thermodynamic parameters by using density functional theory (DFT)
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Rahim, Nida Abd al-Hamid& Kubbah, Ammar Abd al-Razzaq Mahmud. 2018. Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 1, pp.79-88.
https://search.emarefa.net/detail/BIM-838631
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Rahim, Nida Abd al-Hamid& Kubbah, Ammar Abd al-Razzaq Mahmud. Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 1 (2018), pp.79-88.
https://search.emarefa.net/detail/BIM-838631
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Rahim, Nida Abd al-Hamid& Kubbah, Ammar Abd al-Razzaq Mahmud. Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 1, pp.79-88.
https://search.emarefa.net/detail/BIM-838631
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 87-88
رقم السجل
BIM-838631
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر