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Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives
Joint Authors
Kubbah, Ammar Abd al-Razzaq Mahmud
Abd al-Rahim, Nida Abd al-Hamid
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 1 (30 Jun. 2018), pp.79-88, 10 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
2-amino-4-(4-chloro phenyl)-1,3-thiazole (1) was synthesized by refluxing thiourea with para-chloro phenacyl bromide in absolute methanol.
The condensation of amine compound (1) with phenylisothiocyanate in the presence of pyridine will produce 1-(4-(4-chlorophenyl)thiazol-2-yl)-3-phenylthiourea(2), which is upon treatment with 2,4 dinitrophenyl hydrazine by conventional method, afforded 1- ( 4 - ( 4 – chlorophenyl ) thiazol – 2 – yl ) – 3 - phenylhydrazonamide,N' - ( 2 , 4 -dinitrophenyl) ,(3).The characterization of the titled compounds were performed utilizing FTIR spectroscopy, 1HNMR and CHNS elemental analysis, and by measurements of their physical properties.
The synthesized compounds had been screened for their, in vitro preliminary antimicrobial activity against three Gram-positive bacteria: (Staph.
aureus, Micrococcus luteus and Bacillus subtilis) and three Gram-negative bacteria : (Pseud.aeruginosa, E.coli and Proteus mirabilis) ,and two fungal strains(Candida albicans and Candida glabrata ), using a minimum inhibitory concentration (MIC) of 100 µgml of test compound, by well diffusion method.
The derivatives showed moderate antibacterial activity against Gram-positive Staphylococcus aureus and Bacillus subtilis & high antifungal activity against Candida glabrata and Candida albicans.
Computational study was performed to calculate some of thermodynamic parameters by using density functional theory (DFT)
American Psychological Association (APA)
Abd al-Rahim, Nida Abd al-Hamid& Kubbah, Ammar Abd al-Razzaq Mahmud. 2018. Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 1, pp.79-88.
https://search.emarefa.net/detail/BIM-838631
Modern Language Association (MLA)
Abd al-Rahim, Nida Abd al-Hamid& Kubbah, Ammar Abd al-Razzaq Mahmud. Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 1 (2018), pp.79-88.
https://search.emarefa.net/detail/BIM-838631
American Medical Association (AMA)
Abd al-Rahim, Nida Abd al-Hamid& Kubbah, Ammar Abd al-Razzaq Mahmud. Synthesis, characterization and antimicrobial evaluation with DFT study of new two-amino-4-(4-Chlorophenyl) thiazole derivatives. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 1, pp.79-88.
https://search.emarefa.net/detail/BIM-838631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 87-88
Record ID
BIM-838631