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Consequences of hepatorenal toxicity induced by gentamicin in chickens
العناوين الأخرى
عواقب التسميم الكبدي الكلوي بالجينتاميسين في الدجاج
المصدر
Assiut Veterinary Medical Journal
العدد
المجلد 63، العدد 154 (31 يوليو/تموز 2017)، ص ص. 93-104، 12ص.
الناشر
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Gentamicin, one of aminoglycosides, was greatly used in treatment of different bacterial infections in animal.
This study investigated the hepato-nephrotoxicity induced by single intramuscular (IM) injection gentamicin in chickens.
A total number of 90, one day-old, Balady chicks were randomly divided into 3 groups each with 30 birds.
Group (1) served as a control; Group (2) was given 25 mg gentamicin /kg body weight (BW), Group (3) was given 50 mg gentamicin /kg BW.
Hepato-nephrotoxicity was evaluated by measuring growth performances, mortality rats, hematological parameters, biochemical markers; reduced glutathione (GSH), nitric oxide (NO), liver function tests, serum urea and creatinine levels, as well as, by evaluation of histopathological pictures of liver and kidney.
50 mg gentamicin /kg BW reduced growth performance and decreased red blood cell (RBC) count, hemoglobin (Hb) concentration, mean corpuscular hemoglobin concentration (MCHC), total protein, albumin, globulin levels and albumin/ globulin (A/G) ratio.
There were significant heterophilic leukocytosis and eosinophilia.
Levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), urea, creatinine, liver and kidney NO were increased, meanwhile levels of GSH were decreased.
Severe congestion, hemorrhage and multifocal coagulative necrotic areas were microscopically detected in liver and kidneys.
Gentamicin injection altered hematological, biochemical and serum antioxidants pictures and induced hepatic and renal lesions in a dose dependent manner.
The chickens administered 50 mg/kg BW gentamicin were more severely affected than 25 mg/kg BW gentamicin
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arafat, Najih& al-Shafii, Riham Ahmad& Awadayn, Wala Fikri& Faraj, Verginia Muhammad al-Mutawalli& Salih, Rasha Muhammad. 2017. Consequences of hepatorenal toxicity induced by gentamicin in chickens. Assiut Veterinary Medical Journal،Vol. 63, no. 154, pp.93-104.
https://search.emarefa.net/detail/BIM-848731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arafat, Najih…[et al.]. Consequences of hepatorenal toxicity induced by gentamicin in chickens. Assiut Veterinary Medical Journal Vol. 63, no. 154 (Jul. 2017), pp.93-104.
https://search.emarefa.net/detail/BIM-848731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arafat, Najih& al-Shafii, Riham Ahmad& Awadayn, Wala Fikri& Faraj, Verginia Muhammad al-Mutawalli& Salih, Rasha Muhammad. Consequences of hepatorenal toxicity induced by gentamicin in chickens. Assiut Veterinary Medical Journal. 2017. Vol. 63, no. 154, pp.93-104.
https://search.emarefa.net/detail/BIM-848731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
رقم السجل
BIM-848731
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