Consequences of hepatorenal toxicity induced by gentamicin in chickens
Other Title(s)
عواقب التسميم الكبدي الكلوي بالجينتاميسين في الدجاج
Source
Assiut Veterinary Medical Journal
Issue
Vol. 63, Issue 154 (31 Jul. 2017), pp.93-104, 12 p.
Publisher
Assiut University Faculty of Veterinary Medicine
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gentamicin, one of aminoglycosides, was greatly used in treatment of different bacterial infections in animal.
This study investigated the hepato-nephrotoxicity induced by single intramuscular (IM) injection gentamicin in chickens.
A total number of 90, one day-old, Balady chicks were randomly divided into 3 groups each with 30 birds.
Group (1) served as a control; Group (2) was given 25 mg gentamicin /kg body weight (BW), Group (3) was given 50 mg gentamicin /kg BW.
Hepato-nephrotoxicity was evaluated by measuring growth performances, mortality rats, hematological parameters, biochemical markers; reduced glutathione (GSH), nitric oxide (NO), liver function tests, serum urea and creatinine levels, as well as, by evaluation of histopathological pictures of liver and kidney.
50 mg gentamicin /kg BW reduced growth performance and decreased red blood cell (RBC) count, hemoglobin (Hb) concentration, mean corpuscular hemoglobin concentration (MCHC), total protein, albumin, globulin levels and albumin/ globulin (A/G) ratio.
There were significant heterophilic leukocytosis and eosinophilia.
Levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), urea, creatinine, liver and kidney NO were increased, meanwhile levels of GSH were decreased.
Severe congestion, hemorrhage and multifocal coagulative necrotic areas were microscopically detected in liver and kidneys.
Gentamicin injection altered hematological, biochemical and serum antioxidants pictures and induced hepatic and renal lesions in a dose dependent manner.
The chickens administered 50 mg/kg BW gentamicin were more severely affected than 25 mg/kg BW gentamicin
American Psychological Association (APA)
Arafat, Najih& al-Shafii, Riham Ahmad& Awadayn, Wala Fikri& Faraj, Verginia Muhammad al-Mutawalli& Salih, Rasha Muhammad. 2017. Consequences of hepatorenal toxicity induced by gentamicin in chickens. Assiut Veterinary Medical Journal،Vol. 63, no. 154, pp.93-104.
https://search.emarefa.net/detail/BIM-848731
Modern Language Association (MLA)
Arafat, Najih…[et al.]. Consequences of hepatorenal toxicity induced by gentamicin in chickens. Assiut Veterinary Medical Journal Vol. 63, no. 154 (Jul. 2017), pp.93-104.
https://search.emarefa.net/detail/BIM-848731
American Medical Association (AMA)
Arafat, Najih& al-Shafii, Riham Ahmad& Awadayn, Wala Fikri& Faraj, Verginia Muhammad al-Mutawalli& Salih, Rasha Muhammad. Consequences of hepatorenal toxicity induced by gentamicin in chickens. Assiut Veterinary Medical Journal. 2017. Vol. 63, no. 154, pp.93-104.
https://search.emarefa.net/detail/BIM-848731
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-848731