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Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation
المؤلفون المشاركون
Kamal, Ahmad
Kovvuri, Jeshma
Nagaraju, Burri
Ganesh Kumar, C.
Chandrasekhar, Cheemalamarri
al-Urayfi, Abd Allah
Sirisha, K.
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 22، العدد 6 (30 سبتمبر/أيلول 2018)، ص ص. 665-677، 13ص.
الناشر
تاريخ النشر
2018-09-30
دولة النشر
السعودية
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Catalyst-free one-pot CAN and CAC bond formation is described as a simple and ecofriendly method for the synthesis of pyrazole-aniline linked coumarin derivatives.
Employing this protocol, a series of derivatives were synthesized in good to excellent yields and tested against different bacterial strains as well as fungal strains.
Most of the compounds exhibited potential antimicrobial activity against both Gram-positive and Gram-negative bacterial strains.
Among them, the compounds 4b, 4e, 4 h, 4i and 4 k exhibited promising activity on all the tested bacterial strains with values ranging between 1.9 and 7.8 mg/mL.
In addition, these compounds were tested against various fungal strains and were found to exhibit potential antifungal activity.
Fascinatingly, among the tested derivatives, the compounds 4e, 4 h and 4i were found to be equipotent to miconazole (positive control) against some of the tested fungal strains.
Moreover, these compounds showed promising bactericidal, Candida-cidal and biofilm inhibition activities.
Further, mechanistic study was carried out with the most active derivative 4i indicated that these compounds inhibit the ergosterol biosynthesis pathway.
2017 King Saud University.
Production and hosting by Elsevier B.V.
This is an open access article under
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kovvuri, Jeshma& Nagaraju, Burri& Ganesh Kumar, C.& Sirisha, K.& Chandrasekhar, Cheemalamarri& al-Urayfi, Abd Allah…[et al.]. 2018. Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation. Journal of Saudi Chemical Society،Vol. 22, no. 6, pp.665-677.
https://search.emarefa.net/detail/BIM-852163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kovvuri, Jeshma…[et al.]. Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation. Journal of Saudi Chemical Society Vol. 22, no. 6 (Sep. 2018), pp.665-677.
https://search.emarefa.net/detail/BIM-852163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kovvuri, Jeshma& Nagaraju, Burri& Ganesh Kumar, C.& Sirisha, K.& Chandrasekhar, Cheemalamarri& al-Urayfi, Abd Allah…[et al.]. Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation. Journal of Saudi Chemical Society. 2018. Vol. 22, no. 6, pp.665-677.
https://search.emarefa.net/detail/BIM-852163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 677
رقم السجل
BIM-852163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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