Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation
Joint Authors
Kamal, Ahmad
Kovvuri, Jeshma
Nagaraju, Burri
Ganesh Kumar, C.
Chandrasekhar, Cheemalamarri
al-Urayfi, Abd Allah
Sirisha, K.
Source
Journal of Saudi Chemical Society
Issue
Vol. 22, Issue 6 (30 Sep. 2018), pp.665-677, 13 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Saudi Arabia
No. of Pages
13
Main Subjects
Abstract EN
Catalyst-free one-pot CAN and CAC bond formation is described as a simple and ecofriendly method for the synthesis of pyrazole-aniline linked coumarin derivatives.
Employing this protocol, a series of derivatives were synthesized in good to excellent yields and tested against different bacterial strains as well as fungal strains.
Most of the compounds exhibited potential antimicrobial activity against both Gram-positive and Gram-negative bacterial strains.
Among them, the compounds 4b, 4e, 4 h, 4i and 4 k exhibited promising activity on all the tested bacterial strains with values ranging between 1.9 and 7.8 mg/mL.
In addition, these compounds were tested against various fungal strains and were found to exhibit potential antifungal activity.
Fascinatingly, among the tested derivatives, the compounds 4e, 4 h and 4i were found to be equipotent to miconazole (positive control) against some of the tested fungal strains.
Moreover, these compounds showed promising bactericidal, Candida-cidal and biofilm inhibition activities.
Further, mechanistic study was carried out with the most active derivative 4i indicated that these compounds inhibit the ergosterol biosynthesis pathway.
2017 King Saud University.
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This is an open access article under
American Psychological Association (APA)
Kovvuri, Jeshma& Nagaraju, Burri& Ganesh Kumar, C.& Sirisha, K.& Chandrasekhar, Cheemalamarri& al-Urayfi, Abd Allah…[et al.]. 2018. Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation. Journal of Saudi Chemical Society،Vol. 22, no. 6, pp.665-677.
https://search.emarefa.net/detail/BIM-852163
Modern Language Association (MLA)
Kovvuri, Jeshma…[et al.]. Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation. Journal of Saudi Chemical Society Vol. 22, no. 6 (Sep. 2018), pp.665-677.
https://search.emarefa.net/detail/BIM-852163
American Medical Association (AMA)
Kovvuri, Jeshma& Nagaraju, Burri& Ganesh Kumar, C.& Sirisha, K.& Chandrasekhar, Cheemalamarri& al-Urayfi, Abd Allah…[et al.]. Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation. Journal of Saudi Chemical Society. 2018. Vol. 22, no. 6, pp.665-677.
https://search.emarefa.net/detail/BIM-852163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 677
Record ID
BIM-852163