Clinical study on autosomal dominant polycystic kidney disease among North Tunisians
المؤلفون المشاركون
Hajji, Maryam
Hirz Allah, Amal
Karud, Hayah
Qushah, Rim
Abd al-Rahim, Izz al-Din
Haydari, Hafiz
Gorsane, Iman
Bin Hamidah, Fathi
Barbush, Samiyah
Bin Abd Allah, Tayyib
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 30، العدد 1 (28 فبراير/شباط 2019)، ص ص. 175-184، 10ص.
الناشر
تاريخ النشر
2019-02-28
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, which usually manifests in adulthood.
It is characterized by the develop- ment of multiple cysts in the kidneys and many other extrarenal manifestations.
We aimed to determine the factors that contribute to the progression of ADPKD to end-stage renal disease (ESRD).
In a retrospective multicentric study, we reviewed the records of 569 patients with ADPKD, hospitalized at a nephrology department or followed up at the outpatient department of university and regional hospitals, covering the north and center of the country, during the period 1969–2016.
The mean age of the study patients was 48.54 ± 13.68 years and 14% were young adults (<40 years).
There were 272 female and 297 male patients (sex ratio: male/female = 1.09).
A family history of ADPKD was found in 43.7% of cases.
Renal symptoms were dominated by loin pain, renal failure, hypertension, and hematuria, seen in, respectively, 51.9%, 48.2%, 29.1%, and 24.6% of the patients.
The median serum creatinine level was 459 µmol/L (range: 47–2454), and hypertension had preceded the onset of ADPKD in 28.8% of cases.
Extrarenal manifestations consisted of urologic complications (54.6%), liver cysts (43.5%), cardiac involvement (31.9%), cerebral aneurysms (12.9%), and gastrointestinal involvement (9.4%).
ESRD occurred in 43.1% after a mean follow-up of 47 months (range: 0–384).
Risk factors for poor renal prognosis were age >40 years (P = 0.009), hematuria (P = 0.034), hemoglobin >14 g/dL (P = 0.0013), high uric acid level (P = 0.001), and leukocyturia (P = 0.02).
Death occurred in 59 cases (10.3%), mostly
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hajji, Maryam& Barbush, Samiyah& Hirz Allah, Amal& Haydari, Hafiz& Karud, Hayah& Abd al-Rahim, Izz al-Din…[et al.]. 2019. Clinical study on autosomal dominant polycystic kidney disease among North Tunisians. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 1, pp.175-184.
https://search.emarefa.net/detail/BIM-887126
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hajji, Maryam…[et al.]. Clinical study on autosomal dominant polycystic kidney disease among North Tunisians. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 1 (Jan. / Feb. 2019), pp.175-184.
https://search.emarefa.net/detail/BIM-887126
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hajji, Maryam& Barbush, Samiyah& Hirz Allah, Amal& Haydari, Hafiz& Karud, Hayah& Abd al-Rahim, Izz al-Din…[et al.]. Clinical study on autosomal dominant polycystic kidney disease among North Tunisians. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 1, pp.175-184.
https://search.emarefa.net/detail/BIM-887126
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 183-184
رقم السجل
BIM-887126
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر