Clinical study on autosomal dominant polycystic kidney disease among North Tunisians
Joint Authors
Hajji, Maryam
Hirz Allah, Amal
Karud, Hayah
Qushah, Rim
Abd al-Rahim, Izz al-Din
Haydari, Hafiz
Gorsane, Iman
Bin Hamidah, Fathi
Barbush, Samiyah
Bin Abd Allah, Tayyib
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 1 (28 Feb. 2019), pp.175-184, 10 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-02-28
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, which usually manifests in adulthood.
It is characterized by the develop- ment of multiple cysts in the kidneys and many other extrarenal manifestations.
We aimed to determine the factors that contribute to the progression of ADPKD to end-stage renal disease (ESRD).
In a retrospective multicentric study, we reviewed the records of 569 patients with ADPKD, hospitalized at a nephrology department or followed up at the outpatient department of university and regional hospitals, covering the north and center of the country, during the period 1969–2016.
The mean age of the study patients was 48.54 ± 13.68 years and 14% were young adults (<40 years).
There were 272 female and 297 male patients (sex ratio: male/female = 1.09).
A family history of ADPKD was found in 43.7% of cases.
Renal symptoms were dominated by loin pain, renal failure, hypertension, and hematuria, seen in, respectively, 51.9%, 48.2%, 29.1%, and 24.6% of the patients.
The median serum creatinine level was 459 µmol/L (range: 47–2454), and hypertension had preceded the onset of ADPKD in 28.8% of cases.
Extrarenal manifestations consisted of urologic complications (54.6%), liver cysts (43.5%), cardiac involvement (31.9%), cerebral aneurysms (12.9%), and gastrointestinal involvement (9.4%).
ESRD occurred in 43.1% after a mean follow-up of 47 months (range: 0–384).
Risk factors for poor renal prognosis were age >40 years (P = 0.009), hematuria (P = 0.034), hemoglobin >14 g/dL (P = 0.0013), high uric acid level (P = 0.001), and leukocyturia (P = 0.02).
Death occurred in 59 cases (10.3%), mostly
American Psychological Association (APA)
Hajji, Maryam& Barbush, Samiyah& Hirz Allah, Amal& Haydari, Hafiz& Karud, Hayah& Abd al-Rahim, Izz al-Din…[et al.]. 2019. Clinical study on autosomal dominant polycystic kidney disease among North Tunisians. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 1, pp.175-184.
https://search.emarefa.net/detail/BIM-887126
Modern Language Association (MLA)
Hajji, Maryam…[et al.]. Clinical study on autosomal dominant polycystic kidney disease among North Tunisians. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 1 (Jan. / Feb. 2019), pp.175-184.
https://search.emarefa.net/detail/BIM-887126
American Medical Association (AMA)
Hajji, Maryam& Barbush, Samiyah& Hirz Allah, Amal& Haydari, Hafiz& Karud, Hayah& Abd al-Rahim, Izz al-Din…[et al.]. Clinical study on autosomal dominant polycystic kidney disease among North Tunisians. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 1, pp.175-184.
https://search.emarefa.net/detail/BIM-887126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 183-184
Record ID
BIM-887126