New Zn (II)‎ complexes having different coordination modes controlled by the drug furosemide in presence of bioactive nitrogen based ligands : synthesis, structures and various biological applications

العناوين الأخرى

معقدات الزنك ثنائي الشحنة و مختلف طرق الترابط المحكومة بالدواء فوروسميد بوجود القواعد النيتروجينية النشطة : التحضير، التركيب و التطبيقات البيولوجية المختلفة

مقدم أطروحة جامعية

Raymoni, Ghana

مشرف أطروحة جامعية

Abu Ali, Hijazi

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الكيماء

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2018

الملخص الإنجليزي

Novel Zn(II) complexes with the general formula: [Znn(Furo)m(L)z], (n = 1, 2…; m = 1, 2…; z = 1, 2…) were prepared.

The complexes [Zn(furo)2(MeOH)2] (1), [Zn(furo)2(2-ampy)2] (2), [Zn(furo)2(2-ammepy)2] (3), [Zn(furo)2(H2O)(2,2-bipy)] (4), [Zn(furo)2(H2O)(4,4-dipy)] (5), [Zn(furo)2(1,10-phen)] (6), [Zn(furo)2(2,9-dmp)] (7), and [Zn(furo)2(quin)2] (8) were synthesized and characterized using different techniques such as IR, UV-Vis, 1H-NMR, 13C-NMR, LC/MS, single crystal X-ray diffraction and other physical properties.

The crystal structure of complex (4) was determined using single crystal X-ray diffraction.

The anti-bacterial activity of complexes (1-8) was tested using agar diffusion method against three gram-positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis) and three gram-negative bacteria (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa).

Most of the prepared complexes did not show considerable anti-bacterial activity against gram-negative bacteria except complex 4 and complex 6.

The two complexes 4 and 6 showed anti-bacterial activity against P.mirbilis with Inhibition Zone Diameter equals 10.0 mm and complex 6 showed anti-bacterial activity against E.coli with IZD equals 11.7 mm.

In the case of gram-positive bacteria, only complex 3 showed low anti-bacterial activity against S.

epidermidis with IZD equals 6.0 mm.

Complexes 4 and 5 only showed anti-bacterial activity against S.

aureus with IZD equals 8.7 mm and 8.0 mm, respectively.

The complexes 2 and 8 didn’t show any anti-bacterial activity against gram-positive bacteria.

Complex 7 showed anti-bacterial activity for all types of gram-positive bacteria (S.

aureus, B.

subtilis, S.

epidermidis) with IZD equals 8.0 mm, 8.7 mm and 11.3 mm, respectively.

Complex 1 didn’t show any anti-bacterial activity against all types of gram positive and gram negative bacteria.

In addition, the rate of bis-(4- nitrophenyl) phosphate hydrolysis was measured at different temperatures, pH values and concentrations and the rates for the eight complexes were in the following order: complex 4 > 2 > 5 > 8 > 7 > 6 > 3 > 1.

التخصصات الرئيسية

الكيمياء

الموضوعات

• النيتروجين
• مركبات الرصاص
• الفيوروسيميد

عدد الصفحات

87

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-889347