New Zn (II) complexes having different coordination modes controlled by the drug furosemide in presence of bioactive nitrogen based ligands : synthesis, structures and various biological applications
Other Title(s)
معقدات الزنك ثنائي الشحنة و مختلف طرق الترابط المحكومة بالدواء فوروسميد بوجود القواعد النيتروجينية النشطة : التحضير، التركيب و التطبيقات البيولوجية المختلفة
Dissertant
Thesis advisor
University
Birzeit University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2018
English Abstract
Novel Zn(II) complexes with the general formula: [Znn(Furo)m(L)z], (n = 1, 2…; m = 1, 2…; z = 1, 2…) were prepared.
The complexes [Zn(furo)2(MeOH)2] (1), [Zn(furo)2(2-ampy)2] (2), [Zn(furo)2(2-ammepy)2] (3), [Zn(furo)2(H2O)(2,2-bipy)] (4), [Zn(furo)2(H2O)(4,4-dipy)] (5), [Zn(furo)2(1,10-phen)] (6), [Zn(furo)2(2,9-dmp)] (7), and [Zn(furo)2(quin)2] (8) were synthesized and characterized using different techniques such as IR, UV-Vis, 1H-NMR, 13C-NMR, LC/MS, single crystal X-ray diffraction and other physical properties.
The crystal structure of complex (4) was determined using single crystal X-ray diffraction.
The anti-bacterial activity of complexes (1-8) was tested using agar diffusion method against three gram-positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis) and three gram-negative bacteria (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa).
Most of the prepared complexes did not show considerable anti-bacterial activity against gram-negative bacteria except complex 4 and complex 6.
The two complexes 4 and 6 showed anti-bacterial activity against P.mirbilis with Inhibition Zone Diameter equals 10.0 mm and complex 6 showed anti-bacterial activity against E.coli with IZD equals 11.7 mm.
In the case of gram-positive bacteria, only complex 3 showed low anti-bacterial activity against S.
epidermidis with IZD equals 6.0 mm.
Complexes 4 and 5 only showed anti-bacterial activity against S.
aureus with IZD equals 8.7 mm and 8.0 mm, respectively.
The complexes 2 and 8 didn’t show any anti-bacterial activity against gram-positive bacteria.
Complex 7 showed anti-bacterial activity for all types of gram-positive bacteria (S.
aureus, B.
subtilis, S.
epidermidis) with IZD equals 8.0 mm, 8.7 mm and 11.3 mm, respectively.
Complex 1 didn’t show any anti-bacterial activity against all types of gram positive and gram negative bacteria.
In addition, the rate of bis-(4- nitrophenyl) phosphate hydrolysis was measured at different temperatures, pH values and concentrations and the rates for the eight complexes were in the following order: complex 4 > 2 > 5 > 8 > 7 > 6 > 3 > 1.
Main Subjects
Topics
No. of Pages
87
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental.
Chapter Three : Results and discussion.
Chapter Four : Conclusions.
References.
American Psychological Association (APA)
Raymoni, Ghana. (2018). New Zn (II) complexes having different coordination modes controlled by the drug furosemide in presence of bioactive nitrogen based ligands : synthesis, structures and various biological applications. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-889347
Modern Language Association (MLA)
Raymoni, Ghana. New Zn (II) complexes having different coordination modes controlled by the drug furosemide in presence of bioactive nitrogen based ligands : synthesis, structures and various biological applications. (Master's theses Theses and Dissertations Master). Birzeit University. (2018).
https://search.emarefa.net/detail/BIM-889347
American Medical Association (AMA)
Raymoni, Ghana. (2018). New Zn (II) complexes having different coordination modes controlled by the drug furosemide in presence of bioactive nitrogen based ligands : synthesis, structures and various biological applications. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-889347
Language
English
Data Type
Arab Theses
Record ID
BIM-889347
