Chemical studies of flavonoids isolated from Palestinian plants : catmint, crataegus and fenugreek

العناوين الأخرى

دراسة مركبات الفلافونويد المستخلصة من النباتات الفلسطينية : القطرم، الزعرور و الحلبة

مقدم أطروحة جامعية

Rabi, Maysa

مشرف أطروحة جامعية

Rayyan, Salih
Abu Ali, Hijazi

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الكيماء

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2018

الملخص الإنجليزي

Catmint (Nepeta curviflora) is a commonly used medicinal plant native to the Middle East.

In the first part of this research, Nepeta curviflora was extracted followed by chemical analysis and identification of its flavonoids.

Currently, only limited information is available about the chemical constituents of this plant species.

From aerial parts of catmint (Nepeta curviflora) the novel flavone O-glucuronides, ester forms of apigenin 7-O--glucuronopyranosyl-2’’-O-(2”’- O-caffeoyl)--glucuronopyranoside (1) and luteolin 7-O--glucuronopyranosyl-2’’-O-(2”’-O- (caffeoyl)--glucuronopyranoside (2) have been identified.

In addition, ester derivatives of phenolic compounds of rosmarinic acid (3) and caffeic acid (4) have been identified.

The isolated compounds were characterized using Ultra violet -visible spectroscopy (UV-Vis) and extensive use of one-dimensional nuclear magnetic resonance spectroscopy (1D-NMR) and two-dimensional nuclear magnetic resonance spectroscopy (2D-NMR).

In the second part of this research, activated zinc using ultrasound has been introduced as a new tool for reductive reaction to modify flavonoids of fenugreek and Crataegus to anthocyanins.

In-vitro, anti-bacterial activity of original fenugreek, modified fenugreek, original Crataegus and modified Crataegus were investigated against three gram-positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis) and three gram-negative bacteria (Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa) using agar diffusion method.

Unfortunately, all tested sample didn’t show any anti-bacterial activity against all types of gramnegative and gram-positive bacteria.

التخصصات الرئيسية

الكيمياء

الموضوعات

• النباتات الطبية
• فلسطين
• الفلافونويد
• الزعرور
• الحلبة(نبات)

عدد الصفحات

65

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-889348