Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries
المؤلفون المشاركون
Bukiya, Anna N.
Bisen, Shivantika
Dopico, Alex M.
Tobiasz, Ana
Sullivan, Ryan D.
Duncan, Jose
Sullivan, J. Pierce
Davison, Steven
Tate, Danielle L.
Barnett, Stacey
Mari, Giancarlo
Simakova, Maria N.
المصدر
Journal of Drug and Alcohol Research
العدد
المجلد 8، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
تاريخ النشر
2019-12-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Alcohol (ethanol) is one of the most widely consumed drugs.
Alcohol consumption by pregnant women may result in a range of fetal abnormalities termed fetal alcohol spectrum disorders (FASDs).
The cerebrovascular system is emerging as a critical target of alcohol in the developing brain.
We recently showed that three episodes of prenatal alcohol exposure resulting in 80 mg/dL alcohol in maternal blood during mid-pregnancy up-regulated anandamide-induced dilation of fetal cerebral arteries.
Moreover, ethanol dilated fetal cerebral arteries via cannabinoid (CB) receptors.
Whether a critical role of fetal cerebral artery CB system in responses to alcohol was maintained throughout the gestation, remains unknow.
Main methods.
Pregnant baboons (second trimester equivalent) were subjected to three episodes of either alcohol or control drink infusion via gavage.
Cerebral arteries from mothers and near-term female fetuses were in vitro pressurized for diameter monitoring.
Key findings.
Near-term fetal and maternal arteries exhibited similar ability to develop myogenic tone, to constrict in presence of 60 mM KCl, and to respond to 10 μM anandamide.
Fetal and maternal arteries largely failed to dilate in presence of 63 mM ethanol.
No differences were detected between arteries from control and alcohol-exposed baboon donors.
Therefore, previously observed ethanol-induced dilation of fetal cerebral arteries and up-regulation of CB components in response to fetal alcohol exposure during mid-pregnancy was transient and disappeared by near-term.
Significance.
Our findings point at a gestational stage-dependent effect of ethanol on fetal cerebral artery and thus, contribute to our understanding of FASD pathophysiology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Simakova, Maria N.& Tobiasz, Ana& Sullivan, Ryan D.& Bisen, Shivantika& Duncan, Jose& Sullivan, J. Pierce…[et al.]. 2019. Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries. Journal of Drug and Alcohol Research،Vol. 8, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-891966
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Simakova, Maria N.…[et al.]. Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries. Journal of Drug and Alcohol Research Vol. 8 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-891966
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Simakova, Maria N.& Tobiasz, Ana& Sullivan, Ryan D.& Bisen, Shivantika& Duncan, Jose& Sullivan, J. Pierce…[et al.]. Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries. Journal of Drug and Alcohol Research. 2019. Vol. 8, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-891966
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 10-11
رقم السجل
BIM-891966
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر