Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice

العناوين الأخرى

إمكانية التقليل من شدة التهاب الكبد الدهني التغذوي باستخدام الكيكولستيرون في الفئران

المؤلفون المشاركون

Nafir, Sarah Amin
Zalzalah, Munaf Hashim

المصدر

Iraqi Journal of Pharmaceutical Sciences

العدد

المجلد 28، العدد 1 (30 يونيو/حزيران 2019)، ص ص. 17-23، 7ص.

الناشر

جامعة بغداد كلية الصيدلة

تاريخ النشر

2019-06-30

دولة النشر

العراق

عدد الصفحات

7

التخصصات الرئيسية

علم الصيدلة

الملخص EN

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, which is characterized by steatosis, inflammation, and fibrosis.

The aim of this designed study is to evaluate the ability of guggulsterone to prevent high fat diet induced steatohepatitis in mice.

Five groups of male mice were selected and treated as the following: group I, mice had free access to standard commercial diet and considered as control group, group II, mice were fed a specially formulated high-fat diet for 12 weeks to induce non-alcoholic liver disease, while groups III, IV and V the mice were administered high fat diet containing guggulsterone at 500, 1000 and 2000 ppm concentration respectively for 12 weeks.

Maintaining mice on fat rich diet only resulted in inducing the metabolic and histological changes related to NAFLD.

While the treatment with guggulsterone significantly improves the evaluated markers.

These results demonstrate guggulsterone may be useful in preventing the development of steatohepatitis

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nafir, Sarah Amin& Zalzalah, Munaf Hashim. 2019. Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-894609

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nafir, Sarah Amin& Zalzalah, Munaf Hashim. Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.17-23.
https://search.emarefa.net/detail/BIM-894609

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nafir, Sarah Amin& Zalzalah, Munaf Hashim. Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-894609

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 22-23

رقم السجل

BIM-894609