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Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice
Other Title(s)
إمكانية التقليل من شدة التهاب الكبد الدهني التغذوي باستخدام الكيكولستيرون في الفئران
Joint Authors
Nafir, Sarah Amin
Zalzalah, Munaf Hashim
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 1 (30 Jun. 2019), pp.17-23, 7 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, which is characterized by steatosis, inflammation, and fibrosis.
The aim of this designed study is to evaluate the ability of guggulsterone to prevent high fat diet induced steatohepatitis in mice.
Five groups of male mice were selected and treated as the following: group I, mice had free access to standard commercial diet and considered as control group, group II, mice were fed a specially formulated high-fat diet for 12 weeks to induce non-alcoholic liver disease, while groups III, IV and V the mice were administered high fat diet containing guggulsterone at 500, 1000 and 2000 ppm concentration respectively for 12 weeks.
Maintaining mice on fat rich diet only resulted in inducing the metabolic and histological changes related to NAFLD.
While the treatment with guggulsterone significantly improves the evaluated markers.
These results demonstrate guggulsterone may be useful in preventing the development of steatohepatitis
American Psychological Association (APA)
Nafir, Sarah Amin& Zalzalah, Munaf Hashim. 2019. Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-894609
Modern Language Association (MLA)
Nafir, Sarah Amin& Zalzalah, Munaf Hashim. Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.17-23.
https://search.emarefa.net/detail/BIM-894609
American Medical Association (AMA)
Nafir, Sarah Amin& Zalzalah, Munaf Hashim. Possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-894609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 22-23
Record ID
BIM-894609