Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer
العناوين الأخرى
دراسة تحسين الذوبانية لعقار التنوبوسايد بأدراجه بأنابيب نانوية كربونية المعالجة حمضيا و تشتيته ببوليمر مائي
المؤلفون المشاركون
al-Abbud, Raid Mazlum
Gharib, Muwaffaq Muhammad
Abd al-Rasul, Ala Abd al-Husayn
المصدر
Iraqi Journal of Pharmaceutical Sciences
العدد
المجلد 28، العدد 1 (30 يونيو/حزيران 2019)، ص ص. 91-100، 10ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Single walled Carbon nanotubes (SWCNT), as nano-needle structures, are good candidates as nanocarrier delivery systems that can carry drug to the site of action especially for chemotherapy.
Teniposide is an anticancer drug, but it has a problem of low solubility.
In this study, carbon nanotubes properties were improved by pre-functionalized of carbon nanotubes via carboxylation with strong acids and then functionalized through attaching to polymer and copolymer.
Concurrently, a proper polymer-copolymer combination has been selected by the homogeneity and UV-Visible spectroscopy.
The best formula (F19) is further studied utilizing Fourier transoform infra red, scanning electron microscopy, Transmittance electron microscopy, and the solubility of teniposide.
The results showed that the best dispersibility obtained in the formula that used polyvinyl alcohol (PVA) as polymer and polyethylene oxide (PEO) as copolymer at a ratio of 1:1.
The solubility of incorporated teniposide in the selected formula is increased by 11.5 fold.
Accordingly, it can be concluded that the acid treated carbon nanotube and linked by polymer improve the pharmaceutical properties of the carrier and actively increase the potency of drug
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Abbud, Raid Mazlum& Gharib, Muwaffaq Muhammad& Abd al-Rasul, Ala Abd al-Husayn. 2019. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.91-100.
https://search.emarefa.net/detail/BIM-894671
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Abbud, Raid Mazlum…[et al.]. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.91-100.
https://search.emarefa.net/detail/BIM-894671
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Abbud, Raid Mazlum& Gharib, Muwaffaq Muhammad& Abd al-Rasul, Ala Abd al-Husayn. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.91-100.
https://search.emarefa.net/detail/BIM-894671
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 98-100
رقم السجل
BIM-894671
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر