Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer

Other Title(s)

دراسة تحسين الذوبانية لعقار التنوبوسايد بأدراجه بأنابيب نانوية كربونية المعالجة حمضيا و تشتيته ببوليمر مائي

Joint Authors

al-Abbud, Raid Mazlum
Gharib, Muwaffaq Muhammad
Abd al-Rasul, Ala Abd al-Husayn

Source

Iraqi Journal of Pharmaceutical Sciences

Issue

Vol. 28, Issue 1 (30 Jun. 2019), pp.91-100, 10 p.

Publisher

University of Baghdad College of Pharmacy

Publication Date

2019-06-30

Country of Publication

Iraq

No. of Pages

10

Main Subjects

Pharmacology

Abstract EN

Single walled Carbon nanotubes (SWCNT), as nano-needle structures, are good candidates as nanocarrier delivery systems that can carry drug to the site of action especially for chemotherapy.

Teniposide is an anticancer drug, but it has a problem of low solubility.

In this study, carbon nanotubes properties were improved by pre-functionalized of carbon nanotubes via carboxylation with strong acids and then functionalized through attaching to polymer and copolymer.

Concurrently, a proper polymer-copolymer combination has been selected by the homogeneity and UV-Visible spectroscopy.

The best formula (F19) is further studied utilizing Fourier transoform infra red, scanning electron microscopy, Transmittance electron microscopy, and the solubility of teniposide.

The results showed that the best dispersibility obtained in the formula that used polyvinyl alcohol (PVA) as polymer and polyethylene oxide (PEO) as copolymer at a ratio of 1:1.

The solubility of incorporated teniposide in the selected formula is increased by 11.5 fold.

Accordingly, it can be concluded that the acid treated carbon nanotube and linked by polymer improve the pharmaceutical properties of the carrier and actively increase the potency of drug

American Psychological Association (APA)

al-Abbud, Raid Mazlum& Gharib, Muwaffaq Muhammad& Abd al-Rasul, Ala Abd al-Husayn. 2019. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.91-100.
https://search.emarefa.net/detail/BIM-894671

Modern Language Association (MLA)

al-Abbud, Raid Mazlum…[et al.]. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.91-100.
https://search.emarefa.net/detail/BIM-894671

American Medical Association (AMA)

al-Abbud, Raid Mazlum& Gharib, Muwaffaq Muhammad& Abd al-Rasul, Ala Abd al-Husayn. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.91-100.
https://search.emarefa.net/detail/BIM-894671

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 98-100

Record ID

BIM-894671