Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer
Other Title(s)
دراسة تحسين الذوبانية لعقار التنوبوسايد بأدراجه بأنابيب نانوية كربونية المعالجة حمضيا و تشتيته ببوليمر مائي
Joint Authors
al-Abbud, Raid Mazlum
Gharib, Muwaffaq Muhammad
Abd al-Rasul, Ala Abd al-Husayn
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 1 (30 Jun. 2019), pp.91-100, 10 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
Single walled Carbon nanotubes (SWCNT), as nano-needle structures, are good candidates as nanocarrier delivery systems that can carry drug to the site of action especially for chemotherapy.
Teniposide is an anticancer drug, but it has a problem of low solubility.
In this study, carbon nanotubes properties were improved by pre-functionalized of carbon nanotubes via carboxylation with strong acids and then functionalized through attaching to polymer and copolymer.
Concurrently, a proper polymer-copolymer combination has been selected by the homogeneity and UV-Visible spectroscopy.
The best formula (F19) is further studied utilizing Fourier transoform infra red, scanning electron microscopy, Transmittance electron microscopy, and the solubility of teniposide.
The results showed that the best dispersibility obtained in the formula that used polyvinyl alcohol (PVA) as polymer and polyethylene oxide (PEO) as copolymer at a ratio of 1:1.
The solubility of incorporated teniposide in the selected formula is increased by 11.5 fold.
Accordingly, it can be concluded that the acid treated carbon nanotube and linked by polymer improve the pharmaceutical properties of the carrier and actively increase the potency of drug
American Psychological Association (APA)
al-Abbud, Raid Mazlum& Gharib, Muwaffaq Muhammad& Abd al-Rasul, Ala Abd al-Husayn. 2019. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.91-100.
https://search.emarefa.net/detail/BIM-894671
Modern Language Association (MLA)
al-Abbud, Raid Mazlum…[et al.]. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.91-100.
https://search.emarefa.net/detail/BIM-894671
American Medical Association (AMA)
al-Abbud, Raid Mazlum& Gharib, Muwaffaq Muhammad& Abd al-Rasul, Ala Abd al-Husayn. Investigation the improvement of teniposide solubility by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.91-100.
https://search.emarefa.net/detail/BIM-894671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 98-100
Record ID
BIM-894671