Square wave voltammetric and computational study of thyroxine-thiourea interaction

العناوين الأخرى

دراسة فولتامتري الموجة المربعة و حاسوبية للتذاخل ما بين الثايروكسين والثايويوريا

المؤلفون المشاركون

Abd al-Wahhab, Haytham A.
Sulayman, Sad Allah T.
Abd al-Fattah, Marwah N.

المصدر

Rafidain Journal of Science

الناشر

جامعة الموصل كلية العلوم

تاريخ النشر

2019-04-30

دولة النشر

العراق

عدد الصفحات

9

التخصصات الرئيسية

الكيمياء

الموضوعات

• التفاعلات الدوائية
• الثيويوريا
• الثيروكسين

الملخص الإنجليزي

The voltammetric behavior of Thyroxine (T4) was studied using square wave voltammetry in phosphate buffer solution at (pH 7.0) as supporting electrolyte.

Thyroxine gives two well-defined reduction peaks at Ep1 (-0.359) volt and Ep2 (-1.01) volt versus the reference electrode (Ag/AgCl/Sat.KCl).

The calibration curve is linear within a two range of concentration, first is (1.996x10-7 - 19.61x10-7)M with the R2 equal to (0.999) and (0.9963) for Ep1 and Ep2 respectively, and second (0.996x10-6 - 11.857x10-6) M with the R2 equal to (0.9819) and (0.9848) for Ep1 and Ep2 respectively.

The Gibb`s free energy (ΔG), enthalpy (ΔH) and entropy (ΔS) changes of temperature dependent on (K) were calculated using Van`t Hoff equation for Thyroxine and Thiourea binding.

The molecular docking between Thyroxine and Thioureahas been studied, and the results indicates thatthe interaction between T4 and TU was mainly hydrogen bonding and van der Waal`s interaction.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-895025

• APA
• MLA
• AMA