IL-8 and IL-23 levels in peripheral blood mononuclear cells of patients with cutaneous leishmaniasis caused by leishmania major : a case-control study
المؤلفون المشاركون
Khuzai, Narjis
Moghaddas, Ilham
Ridai, Sayyid Abd al-Rahim
Shamsian, Sayyid al-Akbar
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 21، العدد 6 (30 يونيو/حزيران 2019)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Several cytokines contribute to cutaneous leishmaniasis outcomes.
IL-23 is a key cytokine in inflammation and a central cytokine in controlling Th17.
IL-8, alsoknownas a neutrophil chemotactic factor in the lesion site of cutaneous leishmaniasis, indicates disease promotion.
Objectives: This study aimed to evaluate the relationship of Leishmania major with IL-8 and IL-23 expression.
Methods: This case-control study was performed on 25 healthy individuals and 25 cutaneous leishmaniasis patients who lived in Southwestern Iran, in 2017.
Peripheral blood mononuclear cells (PBMCs) were first isolated.
Total RNA was extracted and reversetranscribed into cDNA.
The expression levels of IL-8andIL-23 were measured by the real-timePCR.
The data were statistically analyzed using SPSS version 16.
Results: Our findings indicated that the expression of IL-8 was significantly higher in the leishmaniasis group than in the control group with the median (IQR) of 0.39 (0.92) and 0.03 (0.11), respectively (P = 0.02).
The expression of IL-23 was higher in the leishmaniasis group than in the control group with the median (IQR) of 0.13 (0.43) and 0.11 (0.61), respectively (P = 0.48).
The increased IL-8 expression accompanied the location sites in face and hand and the increased number of skin lesions.
Conclusions: The expression of IL-8 in patients with cutaneous leishmaniasis is an index of increased activity of local neutrophils that can contribute to leishmaniasis survival or inflammation increase.
However, IL-23 appears to be less important in the inflammatory reaction than IL-8.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khuzai, Narjis& Moghaddas, Ilham& Ridai, Sayyid Abd al-Rahim& Shamsian, Sayyid al-Akbar. 2019. IL-8 and IL-23 levels in peripheral blood mononuclear cells of patients with cutaneous leishmaniasis caused by leishmania major : a case-control study. Iranian Red Crescent Medical Journal،Vol. 21, no. 6, pp.1-6.
https://search.emarefa.net/detail/BIM-895925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khuzai, Narjis…[et al.]. IL-8 and IL-23 levels in peripheral blood mononuclear cells of patients with cutaneous leishmaniasis caused by leishmania major : a case-control study. Iranian Red Crescent Medical Journal Vol. 21, no. 6 (Jun. 2019), pp.1-6.
https://search.emarefa.net/detail/BIM-895925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khuzai, Narjis& Moghaddas, Ilham& Ridai, Sayyid Abd al-Rahim& Shamsian, Sayyid al-Akbar. IL-8 and IL-23 levels in peripheral blood mononuclear cells of patients with cutaneous leishmaniasis caused by leishmania major : a case-control study. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 6, pp.1-6.
https://search.emarefa.net/detail/BIM-895925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6
رقم السجل
BIM-895925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر