Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome
المؤلفون المشاركون
Shukri, Dina Muhammad
al-Gamasy, Muhammad A.
Amin, Izzat Kamil
Khalifah, Najla Ali
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 29، العدد 4 (31 أغسطس/آب 2018)، ص ص. 893-901، 9ص.
الناشر
تاريخ النشر
2018-08-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Little was known about the relationships between the T lymphocytes (CD3+), expression of glucocorticoid receptors (GCR) and the response to GC treatment in children with the idiopathic nephrotic syndrome (INS).
Our objective was to determine the relation between steroid responsiveness and GCR expression in T lymphocytes.
The present study was carried out on 80 children with new-onset INS admitted in Pediatric Nephrology Units of Zagazig and Tanta University Hospitals and on 40 healthy children of the same age and sex who served as control group.
The Subjects were subdivided into three groups as follows: Group 1 with 40 healthy children of comparable age and sex served as control group; Group 2 consisted of 60 patients diagnosed with INS with early response to steroid therapy [early responder (ER)] and Group 3 with 20 patients diagnosed with INS with late response to steroid therapy [late responder (LR)].
They were subjected to history taking, focusing on the pattern of response to steroids (ERs), clinical examination, routine laboratory investigations and the GCR/CD3% relationship.
75% of newly diagnosed INS cases were ER whereas 25% were LR.
GCR/CD3% was significantly lower in LR group in comparison with ER and control groups, with a significant negative correlation between time of steroid responsiveness and GCR/CD3%.
LR group showed lower GCR expression in T lymphocytes before starting therapy which may mean that GCR expression could be part of a pathophysiological mechanism of steroid responsiveness in these children and can be used as a useful diagnostic marker to predict steroid responsiveness in patients with INS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amin, Izzat Kamil& al-Gamasy, Muhammad A.& Shukri, Dina Muhammad& Khalifah, Najla Ali. 2018. Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 4, pp.893-901.
https://search.emarefa.net/detail/BIM-896578
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amin, Izzat Kamil…[et al.]. Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 4 (Jul. / Aug. 2018), pp.893-901.
https://search.emarefa.net/detail/BIM-896578
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amin, Izzat Kamil& al-Gamasy, Muhammad A.& Shukri, Dina Muhammad& Khalifah, Najla Ali. Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 4, pp.893-901.
https://search.emarefa.net/detail/BIM-896578
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 900-901
رقم السجل
BIM-896578
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر