Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome
Joint Authors
Shukri, Dina Muhammad
al-Gamasy, Muhammad A.
Amin, Izzat Kamil
Khalifah, Najla Ali
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 4 (31 Aug. 2018), pp.893-901, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-08-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Little was known about the relationships between the T lymphocytes (CD3+), expression of glucocorticoid receptors (GCR) and the response to GC treatment in children with the idiopathic nephrotic syndrome (INS).
Our objective was to determine the relation between steroid responsiveness and GCR expression in T lymphocytes.
The present study was carried out on 80 children with new-onset INS admitted in Pediatric Nephrology Units of Zagazig and Tanta University Hospitals and on 40 healthy children of the same age and sex who served as control group.
The Subjects were subdivided into three groups as follows: Group 1 with 40 healthy children of comparable age and sex served as control group; Group 2 consisted of 60 patients diagnosed with INS with early response to steroid therapy [early responder (ER)] and Group 3 with 20 patients diagnosed with INS with late response to steroid therapy [late responder (LR)].
They were subjected to history taking, focusing on the pattern of response to steroids (ERs), clinical examination, routine laboratory investigations and the GCR/CD3% relationship.
75% of newly diagnosed INS cases were ER whereas 25% were LR.
GCR/CD3% was significantly lower in LR group in comparison with ER and control groups, with a significant negative correlation between time of steroid responsiveness and GCR/CD3%.
LR group showed lower GCR expression in T lymphocytes before starting therapy which may mean that GCR expression could be part of a pathophysiological mechanism of steroid responsiveness in these children and can be used as a useful diagnostic marker to predict steroid responsiveness in patients with INS.
American Psychological Association (APA)
Amin, Izzat Kamil& al-Gamasy, Muhammad A.& Shukri, Dina Muhammad& Khalifah, Najla Ali. 2018. Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 4, pp.893-901.
https://search.emarefa.net/detail/BIM-896578
Modern Language Association (MLA)
Amin, Izzat Kamil…[et al.]. Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 4 (Jul. / Aug. 2018), pp.893-901.
https://search.emarefa.net/detail/BIM-896578
American Medical Association (AMA)
Amin, Izzat Kamil& al-Gamasy, Muhammad A.& Shukri, Dina Muhammad& Khalifah, Najla Ali. Study of glucocorticoid receptors in T lymphocytes (CD3 GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 4, pp.893-901.
https://search.emarefa.net/detail/BIM-896578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 900-901
Record ID
BIM-896578