The protective effects of honey and spirulina platensis on acetic acid-induced ulcerative colitis in rats
المؤلفون المشاركون
Iftikhari, Muhammad Hassan
Ridai, Nadiyah
Tanidih, Nadir
Mukhtari, Mral
Baqiri, Zahrah
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 20، العدد 4 (30 إبريل/نيسان 2018)، ص ص. 1-11، 11ص.
الناشر
تاريخ النشر
2018-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background : Overproduction of reactive oxygen species (ROS) causes increased lipid peroxidation, decreased intestinal epithelial barrier integrity, and ultimately mucosal disruption and ulceration.
Several studies have confirmed the antioxidant, antiinflammatory, and immunomodulatory properties of Spirulina Platensis (SP), edible blue - green algae, in various inflammatory diseases.
In addition, natural honey, a source of phenolic and flavonoid compounds, is a powerful antioxidant, which can help prevent chronic oxidative stress and subsequent inflammation.
Objectives : In this study, we examined and compared the protective effects of SP and honey on ulcerative colitis induced by acetic acid (AA) in rats.
Methods : Forty male rats were allocated into five groups (N = 8) and received pretreatment for 32 consecutive days.
The administrations were as follows: group 1 (control) and group 2 (AA-colitis group): normal saline, group 3: 1 ml honey/day, group 4: 1 ml honey/day plus 1 g/kg SP, and group 5: 1 g/kg SP.
Colitis was induced on the 30th day in groups 2 to 5.
On day 32, the clinical activity score was determined and anesthetized animals were sacrificed.
Serum interleukin-6 (IL-6), IL-1 , tumor necrosis factor- (TNF- ), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), myeloperoxidase (MPO), prostaglandin E2 (PGE2), malondialdehyde (MDA), nitric oxide (NO), and colonic weight/length ratio were determined.
In addition, histopathological changes of the colon were observed microscopically.
Results : Theinflammatory markers (PGE2, MDA,NO, IL-6, IL-1 ,MPO,andTNF- ) were significantly lower in the pretreatment groups than in the AA-colitis group (P values < 0.05).
PGE2 [median (IQR)] of the honey, SP + honey, and SP groups was [0.76 (0.33)], [0.75 (0.40)], and [0.87 (0.86)], respectively, compared to the AA-colitis group [2.60 (2.23)] (P values < 0.041).
MDA values were [6.52 (3.57)], [6.09 (3.59)], and [5.85 (4.92)] vs.
[16.60 (12.03)] (P values < 0.046) and IL-1 values were [42.20 (8.2)], [41.76 (18.10)], and [42.93 (14.09)] vs.
[79.54 (40.79)] (P values < 0.044).
Also, SOD, GSH, GPx, and TAC [median (IQR)] were significantly higher in the pretreatment groups than in the AA- colitis group (P values < 0.05).
For example, TAC values of the honey, SP + honey, and SP groups were [0.164 (0.08)], [0.14 (0.05)], and [0.16 (0.10)], respectively, vs.
the AA-colitis group [0.08 (0.01)] (P values < 0.028).
Conclusions : Honey and SP are favorable foods in preventing oxidative stress and inflammatory diseases such as ulcerative colitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ridai, Nadiyah& Iftikhari, Muhammad Hassan& Tanidih, Nadir& Mukhtari, Mral& Baqiri, Zahrah. 2018. The protective effects of honey and spirulina platensis on acetic acid-induced ulcerative colitis in rats. Iranian Red Crescent Medical Journal،Vol. 20, no. 4, pp.1-11.
https://search.emarefa.net/detail/BIM-897743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ridai, Nadiyah…[et al.]. The protective effects of honey and spirulina platensis on acetic acid-induced ulcerative colitis in rats. Iranian Red Crescent Medical Journal Vol. 20, no. 4 (Apr. 2018), pp.1-11.
https://search.emarefa.net/detail/BIM-897743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ridai, Nadiyah& Iftikhari, Muhammad Hassan& Tanidih, Nadir& Mukhtari, Mral& Baqiri, Zahrah. The protective effects of honey and spirulina platensis on acetic acid-induced ulcerative colitis in rats. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 4, pp.1-11.
https://search.emarefa.net/detail/BIM-897743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 9-11
رقم السجل
BIM-897743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر