Tamoxifen Effects on the lipid profile in premenopausal women with Breast cancer : a follow up study

الملخص EN

Background : Breast cancer composed of several biologic subtypes that have response to hormonal therapy.

Tamoxifen is hormonal therapy with tissue- pecific antagonistic or agonist effects, the latter being responsible for multiple effects on lipid metabolism in women .

Objective : This study was designed to determine the impact of Tamoxifen on the serum lipid profile in breast cancer women.

Patients and methods : Prospective observation cohort study conducted at Oncology Teaching Hospital, Medical city complx.starting from October 2015 to October 2016.

A total number of 40 premenopausal women with breast cancer were enrolled in this study according to inclusion criteria .

Patients were followed for three months by the measurements TC, TG, HDL – cholesterol and BMI .

Results : At the end of third months of hormonal therapy, Tamoxifen showed a significant decrease in TG, VLDL (p< 0.001 for both).

On the other side HDL and BMI showed significant increase over three months duration , (p = 0.001 and 0.006, respectively) .

Conclusion : Beneficial alterations of lipid profiles were seen in pre-menopausal breast cancer patients treated with Tamoxifen.