The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats
العناوين الأخرى
التأثير الوقائي لمرافق الأنزيم 10-Q و الاندروستيرون منزوع ثنائي الأوكسجين و مزجهما في التقليل من التأثير السمي و تشوهات الأجنة الناتج لعقار النورفلوكساسين في إناث الجرذان الحوامل
المؤلفون المشاركون
al-Sawwad, Ala Abd al-Khaliq Husayn
al-Rikabi, Basim Khamis Kuti
al-Diwan, Muhammad Ali Muhammad
المصدر
Basrah Journal of Veterinary Research
العدد
المجلد 17، العدد 2 (31 ديسمبر/كانون الأول 2018)، ص ص. 204-227، 24ص.
الناشر
جامعة البصرة كلية الطب البيطري
تاريخ النشر
2018-12-31
دولة النشر
العراق
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
This study was designed to evaluate the protective effect of CoQ10 and DHEA and their combination on norfloxacin induced embryotoxicity and teratogenicity in pregnant female rats and their fetuses.
Twenty pregnant rats were divided equally into 5 groups, 4 animals each group as following: Control group (G1): 4 normal pregnant female received orally DMSO 0.5ml/animal/day from 5th - 19th day of gestation, first treated group (T1): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily, second treated group (T2): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily and after 1hours injected daily with CoQ10 200 mg/kg IP, third treated group (T3): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily and after 1hours injected daily with DHEA 25 mg/kg IP, and fourth treated group (T4): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily and after 1hours injected daily with a combination of CoQ10 200 mg/kg and DHEA 25 mg/kg IP for the same period.
Norfloxacin was administered by oral gavages as a single dose.
All dams were sacrificed at 20th day of gestation and their fetuses were collected and subjected to morphological and skeletal examinations.
The obtained results showed that exposure to norfloxacin in pregnant female rats during gestational period from 5th -19th day demonstrated a significant increased (P≤ 0.05) in resorbed and stillbirth fetuses (dead fetuses at birth), and a significant decrease in fetal body weight, fetal body length, fetal tail length, maternal weight gain and placental weight; and also caused skeletal malformation in all cranial bone compared to control group.
It has been concluded that CoQ10 and DHEA prevented and treated morphological and skeletal anomalies in rat fetuses.
Therefore, CoQ10 and DHEA are potential therapeutic antioxidant agents against fetotoxicity and teratogenicity induced by oxidative stress generated by norfloxacin intoxication
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Rikabi, Basim Khamis Kuti& al-Diwan, Muhammad Ali Muhammad& al-Sawwad, Ala Abd al-Khaliq Husayn. 2018. The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats. Basrah Journal of Veterinary Research،Vol. 17, no. 2, pp.204-227.
https://search.emarefa.net/detail/BIM-900470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Rikabi, Basim Khamis Kuti…[et al.]. The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats. Basrah Journal of Veterinary Research Vol. 17, no. 2 (2018), pp.204-227.
https://search.emarefa.net/detail/BIM-900470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Rikabi, Basim Khamis Kuti& al-Diwan, Muhammad Ali Muhammad& al-Sawwad, Ala Abd al-Khaliq Husayn. The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats. Basrah Journal of Veterinary Research. 2018. Vol. 17, no. 2, pp.204-227.
https://search.emarefa.net/detail/BIM-900470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 222-227
رقم السجل
BIM-900470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر