The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats
Other Title(s)
التأثير الوقائي لمرافق الأنزيم 10-Q و الاندروستيرون منزوع ثنائي الأوكسجين و مزجهما في التقليل من التأثير السمي و تشوهات الأجنة الناتج لعقار النورفلوكساسين في إناث الجرذان الحوامل
Joint Authors
al-Sawwad, Ala Abd al-Khaliq Husayn
al-Rikabi, Basim Khamis Kuti
al-Diwan, Muhammad Ali Muhammad
Source
Basrah Journal of Veterinary Research
Issue
Vol. 17, Issue 2 (31 Dec. 2018), pp.204-227, 24 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
24
Main Subjects
Abstract EN
This study was designed to evaluate the protective effect of CoQ10 and DHEA and their combination on norfloxacin induced embryotoxicity and teratogenicity in pregnant female rats and their fetuses.
Twenty pregnant rats were divided equally into 5 groups, 4 animals each group as following: Control group (G1): 4 normal pregnant female received orally DMSO 0.5ml/animal/day from 5th - 19th day of gestation, first treated group (T1): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily, second treated group (T2): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily and after 1hours injected daily with CoQ10 200 mg/kg IP, third treated group (T3): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily and after 1hours injected daily with DHEA 25 mg/kg IP, and fourth treated group (T4): 4 normal pregnant female received orally 400 mg/kg norfloxacin once daily and after 1hours injected daily with a combination of CoQ10 200 mg/kg and DHEA 25 mg/kg IP for the same period.
Norfloxacin was administered by oral gavages as a single dose.
All dams were sacrificed at 20th day of gestation and their fetuses were collected and subjected to morphological and skeletal examinations.
The obtained results showed that exposure to norfloxacin in pregnant female rats during gestational period from 5th -19th day demonstrated a significant increased (P≤ 0.05) in resorbed and stillbirth fetuses (dead fetuses at birth), and a significant decrease in fetal body weight, fetal body length, fetal tail length, maternal weight gain and placental weight; and also caused skeletal malformation in all cranial bone compared to control group.
It has been concluded that CoQ10 and DHEA prevented and treated morphological and skeletal anomalies in rat fetuses.
Therefore, CoQ10 and DHEA are potential therapeutic antioxidant agents against fetotoxicity and teratogenicity induced by oxidative stress generated by norfloxacin intoxication
American Psychological Association (APA)
al-Rikabi, Basim Khamis Kuti& al-Diwan, Muhammad Ali Muhammad& al-Sawwad, Ala Abd al-Khaliq Husayn. 2018. The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats. Basrah Journal of Veterinary Research،Vol. 17, no. 2, pp.204-227.
https://search.emarefa.net/detail/BIM-900470
Modern Language Association (MLA)
al-Rikabi, Basim Khamis Kuti…[et al.]. The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats. Basrah Journal of Veterinary Research Vol. 17, no. 2 (2018), pp.204-227.
https://search.emarefa.net/detail/BIM-900470
American Medical Association (AMA)
al-Rikabi, Basim Khamis Kuti& al-Diwan, Muhammad Ali Muhammad& al-Sawwad, Ala Abd al-Khaliq Husayn. The protective effect of coq10, dhea and their combination in reduced embryotoxicity and teratogenicity for norfloxacin in pregnant female rats. Basrah Journal of Veterinary Research. 2018. Vol. 17, no. 2, pp.204-227.
https://search.emarefa.net/detail/BIM-900470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 222-227
Record ID
BIM-900470