Cystatin C and some biochemical parameters for dialysis adequacy among Hemodialysed patients at Al-Shifa Hospital, Gaza-Governorate

العناوين الأخرى

سيستاتين سي و بعض المعايير البيوكيميائية لقياس كفاءة الغسيل الدموي لدى مرضى الفشل الكلوي المزمن في مستشفى الشفاء-محافظة غزة

مقدم أطروحة جامعية

al-Ijlah, Fawwaz Hasan Muhammad

مشرف أطروحة جامعية

al-Zabut, Bakr Mahmud

الجامعة

الجامعة الإسلامية

الكلية

كلية العلوم

القسم الأكاديمي

قسم العلوم الحياتية

دولة الجامعة

فلسطين (قطاع غزة)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2018

الملخص الإنجليزي

Background: Chronic kidney disease (CKD) is a global public health problem with increasing incidence, prevalence, high morbidity and mortality.

CKD is a progressive and irreversible loss of renal function and finally complete loss of kidney function or kidney damage, that is, end-stage renal disease (ESRD).

Cystatin C (Cys-C) correlates with direct measures of glomerular filtration rate (GFR) more precisely than creatinine.

Objective: To evaluate Cys-C and some biochemical parameters for dialysis adequacy among hemodialysed patients at Al-Shifa hospital, Gaza governorate.

Materials and Methods: This study design was observational cross section pre and post design.

It was carried out in Gaza Governorate.

A total of 80 CKD with ESRD patients, on regular twice or three-weekly 4-hour hemodialysis, divided into 40 males and 40 females.

Anthropometric evaluation and biochemical detection were carried out for kidney function, total protein, albumin, phosphorus, electrolytes, glucose, lipid profile and Cys-C were measured in a single treatment at pre and post dialysis.

The data were analyzed using SPSS version 22.

Results: All of the 80 patients were kidney dialyzed in 32 dialysis machines.

About 66 (82.5%) were used less than 5 years whereas the rest number were old machine 14 (17.5%).

The result showed that there was a highly decrease significant in body mass index (BMI) and weight among the study population (P=0.000).

Moreover, a highly decrease significant in urea, creatinine, uric acid and Cys-C were observed (P=0.000).

In addition, a highly increase significant level in glucose, lipid profile, total protein and albumin were observed (P=0.000).

Furthermore, a highly increase significant in blood Na+ , tCa+ and iCa++ while decrease in K + , Cland phosphorus levels were observed (P=0.000).

In the other hands, the results showed that there was no significant relation between Cys-C reduction ratio (CCRR) with urea reduction ratio (URR), and creatinine reduction ratio (CrRR).

Furthermore, the results showed that there was significant correlation between the URR with, Kt/V, SP-Kt/V, CrRR and CCRR (r>65.0%, P<0.05).

Moreover, there were no significant differences between Kt/V and SP-Kt/V among study population (P=0.006), that have the same adequacy dose of dialysis.

In addition, our findings showed that the percent adequacy cutoff value for CrRR was 62.75% and 24.03% for CCRR Conclusions: Hemodialysis have highly decrease significant effect on BMI, weight and blood pressure, urea, creatinine, uric acid and Cys-C levels among of study population.

The estimated adequacy cutoff value was 62.75% for CrRR and 24.03% for CCRR.

Furthermore, the Kt/V and SP-Kt/V they showed the same adequacy dose of dialysis

التخصصات الرئيسية

الأحياء
الطب البشري

الموضوعات

• غسيل الكلى
• قطاع غزة
• سيستاتين سي

عدد الصفحات

141

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-900708