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Cystatin C and some biochemical parameters for dialysis adequacy among Hemodialysed patients at Al-Shifa Hospital, Gaza-Governorate
Other Title(s)
سيستاتين سي و بعض المعايير البيوكيميائية لقياس كفاءة الغسيل الدموي لدى مرضى الفشل الكلوي المزمن في مستشفى الشفاء-محافظة غزة
Dissertant
al-Ijlah, Fawwaz Hasan Muhammad
Thesis advisor
University
Islamic University
Faculty
Faculty of Science
Department
Department of Biological Science
University Country
Palestine (Gaza Strip)
Degree
Master
Degree Date
2018
English Abstract
Background: Chronic kidney disease (CKD) is a global public health problem with increasing incidence, prevalence, high morbidity and mortality.
CKD is a progressive and irreversible loss of renal function and finally complete loss of kidney function or kidney damage, that is, end-stage renal disease (ESRD).
Cystatin C (Cys-C) correlates with direct measures of glomerular filtration rate (GFR) more precisely than creatinine.
Objective: To evaluate Cys-C and some biochemical parameters for dialysis adequacy among hemodialysed patients at Al-Shifa hospital, Gaza governorate.
Materials and Methods: This study design was observational cross section pre and post design.
It was carried out in Gaza Governorate.
A total of 80 CKD with ESRD patients, on regular twice or three-weekly 4-hour hemodialysis, divided into 40 males and 40 females.
Anthropometric evaluation and biochemical detection were carried out for kidney function, total protein, albumin, phosphorus, electrolytes, glucose, lipid profile and Cys-C were measured in a single treatment at pre and post dialysis.
The data were analyzed using SPSS version 22.
Results: All of the 80 patients were kidney dialyzed in 32 dialysis machines.
About 66 (82.5%) were used less than 5 years whereas the rest number were old machine 14 (17.5%).
The result showed that there was a highly decrease significant in body mass index (BMI) and weight among the study population (P=0.000).
Moreover, a highly decrease significant in urea, creatinine, uric acid and Cys-C were observed (P=0.000).
In addition, a highly increase significant level in glucose, lipid profile, total protein and albumin were observed (P=0.000).
Furthermore, a highly increase significant in blood Na+ , tCa+ and iCa++ while decrease in K + , Cland phosphorus levels were observed (P=0.000).
In the other hands, the results showed that there was no significant relation between Cys-C reduction ratio (CCRR) with urea reduction ratio (URR), and creatinine reduction ratio (CrRR).
Furthermore, the results showed that there was significant correlation between the URR with, Kt/V, SP-Kt/V, CrRR and CCRR (r>65.0%, P<0.05).
Moreover, there were no significant differences between Kt/V and SP-Kt/V among study population (P=0.006), that have the same adequacy dose of dialysis.
In addition, our findings showed that the percent adequacy cutoff value for CrRR was 62.75% and 24.03% for CCRR Conclusions: Hemodialysis have highly decrease significant effect on BMI, weight and blood pressure, urea, creatinine, uric acid and Cys-C levels among of study population.
The estimated adequacy cutoff value was 62.75% for CrRR and 24.03% for CCRR.
Furthermore, the Kt/V and SP-Kt/V they showed the same adequacy dose of dialysis
Main Subjects
Topics
No. of Pages
141
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Subjects and methods.
Chapter Four : Result.
Chapter Five : Discussion.
Chapter Six : Conclusions and recommendations.
References.
American Psychological Association (APA)
al-Ijlah, Fawwaz Hasan Muhammad. (2018). Cystatin C and some biochemical parameters for dialysis adequacy among Hemodialysed patients at Al-Shifa Hospital, Gaza-Governorate. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-900708
Modern Language Association (MLA)
al-Ijlah, Fawwaz Hasan Muhammad. Cystatin C and some biochemical parameters for dialysis adequacy among Hemodialysed patients at Al-Shifa Hospital, Gaza-Governorate. (Master's theses Theses and Dissertations Master). Islamic University. (2018).
https://search.emarefa.net/detail/BIM-900708
American Medical Association (AMA)
al-Ijlah, Fawwaz Hasan Muhammad. (2018). Cystatin C and some biochemical parameters for dialysis adequacy among Hemodialysed patients at Al-Shifa Hospital, Gaza-Governorate. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-900708
Language
English
Data Type
Arab Theses
Record ID
BIM-900708