Synthesis and evaluation the activity of 1,3,4-thiadiazole derivatives as antibacterial agent against uncommon bacteria causes of urinary tract infections

العناوين الأخرى

تصنيع و تقييم فعالية مشتقات 1,3,4-Thiadiazole كعامل مضاد للبكتريا غير الشائعة المسببة لالتهابات المسالك البولية

المؤلفون المشاركون

Dahham, Shayma N.
Abd al-Wahhab, Marwah H.
Mahmud, Asma E.
Akram, Ivon

المصدر

Rafidain Journal of Science

الناشر

جامعة الموصل كلية العلوم

تاريخ النشر

2018-10-31

دولة النشر

العراق

عدد الصفحات

13

التخصصات الرئيسية

الأحياء
الطب البشري

الملخص الإنجليزي

Schiff base compound 5-(benzylideneamino)-1,3,4-thiadiazole-2-thiol was prepared from condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with benzaldehyde.

New Schiff bases react with copper (II), Ferric (III), Cobalt (II) and Zinc (II) to form four complexes.

The Schiff base complexes were identification by using FTIR and UV-VIS.

The antibacterial activity of complexes (Copper (II) LM1, Ferric (III) LM2, Cobalt (II) LM3 and Zinc (II) LM4 complexes) were studied against Kocuria kristinae, Alloiococcus otiti and Aerococcus urinae as a model of Gram positive, Pseudomonas stutzeri, Ochrobactrum anthropic and Pantoea agglomerans as a model of Gram negative to determine the activity of synthesized complexes.

Identification of these uncommon bacteria that isolated from urinary tract infection confirmed by using VITEK2 compact system.

Several antibiotics have been chosen to investigate the ability of these isolates to resist the conventional antibiotic.

The results showed higher activity of the new compounds relative to the chosen antibiotics.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-902263

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