MTHFR C677T polymorphism and risk of esophageal cancer : an updated meta-analysis
المؤلفون المشاركون
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 4 (31 أكتوبر/تشرين الأول 2018)، ص ص. 273-284، 12ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-10-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate/homocysteine metabolism.
A polymorphism C677T has been reported to be linked with risk of several diseases/ disorders like birth defects, metabolic and psychiatric disorders and different cancers.
The association between esophageal cancer and MTHFR gene C677T polymorphism has been investigated in several case-control studies, which rendered contradictory results.
Aim: To shed light on association between MTHFR C677T polymorphism and risk of esophageal cancer, a meta-analysis of published case control association studies was conducted.
Methods: Four electronic databases: PubMed, Google Scholars, Elsevier and Springer Link were searched up to August 2016.
All statistical analyses were performed using MetaAnalyst and Mix (version 1.7).
Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated.
Total twenty-nine studies with 6520 cases and 9192 controls were included in the present meta-analysis.
Results: The results of meta-analysis suggested that there were significant association between C677T polymorphism and esophageal cancer risk using overall comparisons in five genetic models (T vs.
C: OR = 1.20, 95% CI = 1.1–1.27, p = <0.0001; TT + CT vs.
CC: OR = 1.37, 95% CI = 1.14–1.62, p = 0.0004; TT vs.
CC: OR = 1.43, 95% CI = 1.1–1.84, p = 0.005; CT vs.
CC OR = 1.35, 95% CI = 1.15–1.58, p = 0.0002; TT vs.
CT + CC: OR = 1.19, 95% CI = 0.99–1.42, p = 0.05).
Publication bias was absent.
Subgroup analysis based on ethnicity and source of controls were also performed.
Conclusion: In conclusion, results of present meta-analysis showed significant association between MTHFR C677T polymorphism and esophageal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kumar, Pradeep& Rai, Vandana. 2018. MTHFR C677T polymorphism and risk of esophageal cancer : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 4, pp.273-284.
https://search.emarefa.net/detail/BIM-902362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kumar, Pradeep& Rai, Vandana. MTHFR C677T polymorphism and risk of esophageal cancer : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 4 (Oct. 2018), pp.273-284.
https://search.emarefa.net/detail/BIM-902362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kumar, Pradeep& Rai, Vandana. MTHFR C677T polymorphism and risk of esophageal cancer : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 4, pp.273-284.
https://search.emarefa.net/detail/BIM-902362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 283-284
رقم السجل
BIM-902362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر