MTHFR C677T polymorphism and risk of esophageal cancer : an updated meta-analysis

Abstract EN

Background: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate/homocysteine metabolism.

A polymorphism C677T has been reported to be linked with risk of several diseases/ disorders like birth defects, metabolic and psychiatric disorders and different cancers.

The association between esophageal cancer and MTHFR gene C677T polymorphism has been investigated in several case-control studies, which rendered contradictory results.

Aim: To shed light on association between MTHFR C677T polymorphism and risk of esophageal cancer, a meta-analysis of published case control association studies was conducted.

Methods: Four electronic databases: PubMed, Google Scholars, Elsevier and Springer Link were searched up to August 2016.

All statistical analyses were performed using MetaAnalyst and Mix (version 1.7).

Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated.

Total twenty-nine studies with 6520 cases and 9192 controls were included in the present meta-analysis.

Results: The results of meta-analysis suggested that there were significant association between C677T polymorphism and esophageal cancer risk using overall comparisons in five genetic models (T vs.

C: OR = 1.20, 95% CI = 1.1–1.27, p = <0.0001; TT + CT vs.

CC: OR = 1.37, 95% CI = 1.14–1.62, p = 0.0004; TT vs.

CC: OR = 1.43, 95% CI = 1.1–1.84, p = 0.005; CT vs.

CC OR = 1.35, 95% CI = 1.15–1.58, p = 0.0002; TT vs.

CT + CC: OR = 1.19, 95% CI = 0.99–1.42, p = 0.05).

Publication bias was absent.

Subgroup analysis based on ethnicity and source of controls were also performed.

Conclusion: In conclusion, results of present meta-analysis showed significant association between MTHFR C677T polymorphism and esophageal cancer.