Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro
العناوين الأخرى
تقييم النشاط المضاد للتسرطن لخالصة المرجان الناعم ساركوفيتون غالكم في خاليا ابيضاض دم الفئران داخل و خارج الحيوان
المؤلفون المشاركون
al-Matri, Muhammad Ali
al-Asuli, Sufyan Muhammad
al-Baqmi, Najah Muhammad Hamid
al-Asuli, Muhammad Zaki Mustafa
Abu Zinadah, Usamah Abd Allah
Anwar, Yasir
المصدر
Journal of King Abdulaziz University : Sciences
العدد
المجلد 29، العدد 2 (31 ديسمبر/كانون الأول 2017)، ص ص. 31-47، 17ص.
الناشر
جامعة الملك عبد العزيز مركز النشر العلمي
تاريخ النشر
2017-12-31
دولة النشر
السعودية
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Marine environment biodiversity opens up new horizons in the quest for bioactive compounds that could be utilized as antitumor agents.
Soft Coral Sarcophyton glaucum is an important folk medicinal marine.
It has anti-oxidant, anticarcinogenic.
The objectives of present study are to investigatimg in vitro the antiproliferative activity of sarcophine extract on mouse Leukemia cells (L1210), also, we shall evaluate in vivo the antitumor activity of the soft coral S.
glaucum extract against Mouse Leukemia cells (L1210), on mice (Swiss albino mice).
The antiproliferative and cytotoxic activities of the S.
glaucum were determined using the trypan blue dye exclusion and the WST-1 cell proliferation tests.
The underlying possible mechanism of cell death was investigated whether it is necrotic or apoptotic by single cell gel electrophoresis (comet assay) and dual acridine orange/ethidium bromide (AO/EB) staining.
The antitumor activity of the S.
glaucum extract against mouse leukemia cell line, L1210, grown as ascites in mouse model.
In vitro Results showed that S.
glaucum inhibited L1210 cancer cells proliferation and induced apoptosis and that the apoptotic activities.
The mechanism underlying cell death was due to induction of apoptosis, which was associated by DNA damage and morphological changes of the treated cells.
In vivo study indicated that S.
glaucum has ability to suppress cancer progression in treated animals.
These findings indicate that the S.
glaucum extract can be a candidate agent for fighting cancer), on mice (Swiss albino mice).
The antiproliferative and cytotoxic activities of the S.
glaucum were determined using the trypan blue dye exclusion and the WST-1 cell proliferation tests.
The underlying possible mechanism of cell death was investigated whether it is necrotic or apoptotic by single cell gel electrophoresis (comet assay) and dual acridine orange/ethidium bromide (AO/EB) staining.
The antitumor activity of the S.
glaucum extract against mouse leukemia cell line, L1210, grown as ascites in mouse model.
In vitro Results showed that S.
glaucum inhibited L1210 cancer cells proliferation and induced apoptosis and that the apoptotic activities.
The mechanism underlying cell death was due to induction of apoptosis, which was associated by DNA damage and morphological changes of the treated cells.
In vivo study indicated that S.
glaucum has ability to suppress cancer progression in treated animals.
These findings indicate that the S.
glaucum extract can be a candidate agent for fighting cance
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Baqmi, Najah Muhammad Hamid& Abu Zinadah, Usamah Abd Allah& al-Asuli, Muhammad Zaki Mustafa& al-Matri, Muhammad Ali& Anwar, Yasir& al-Asuli, Sufyan Muhammad. 2017. Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro. Journal of King Abdulaziz University : Sciences،Vol. 29, no. 2, pp.31-47.
https://search.emarefa.net/detail/BIM-903031
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Baqmi, Najah Muhammad Hamid…[et al.]. Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro. Journal of King Abdulaziz University : Sciences Vol. 29, no. 2 (2017), pp.31-47.
https://search.emarefa.net/detail/BIM-903031
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Baqmi, Najah Muhammad Hamid& Abu Zinadah, Usamah Abd Allah& al-Asuli, Muhammad Zaki Mustafa& al-Matri, Muhammad Ali& Anwar, Yasir& al-Asuli, Sufyan Muhammad. Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro. Journal of King Abdulaziz University : Sciences. 2017. Vol. 29, no. 2, pp.31-47.
https://search.emarefa.net/detail/BIM-903031
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 44-46
رقم السجل
BIM-903031
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر