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Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro
Other Title(s)
تقييم النشاط المضاد للتسرطن لخالصة المرجان الناعم ساركوفيتون غالكم في خاليا ابيضاض دم الفئران داخل و خارج الحيوان
Joint Authors
al-Matri, Muhammad Ali
al-Asuli, Sufyan Muhammad
al-Baqmi, Najah Muhammad Hamid
al-Asuli, Muhammad Zaki Mustafa
Abu Zinadah, Usamah Abd Allah
Anwar, Yasir
Source
Journal of King Abdulaziz University : Sciences
Issue
Vol. 29, Issue 2 (31 Dec. 2017), pp.31-47, 17 p.
Publisher
King Abdulaziz University Scientific Publishing Center
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
17
Main Subjects
Abstract EN
Marine environment biodiversity opens up new horizons in the quest for bioactive compounds that could be utilized as antitumor agents.
Soft Coral Sarcophyton glaucum is an important folk medicinal marine.
It has anti-oxidant, anticarcinogenic.
The objectives of present study are to investigatimg in vitro the antiproliferative activity of sarcophine extract on mouse Leukemia cells (L1210), also, we shall evaluate in vivo the antitumor activity of the soft coral S.
glaucum extract against Mouse Leukemia cells (L1210), on mice (Swiss albino mice).
The antiproliferative and cytotoxic activities of the S.
glaucum were determined using the trypan blue dye exclusion and the WST-1 cell proliferation tests.
The underlying possible mechanism of cell death was investigated whether it is necrotic or apoptotic by single cell gel electrophoresis (comet assay) and dual acridine orange/ethidium bromide (AO/EB) staining.
The antitumor activity of the S.
glaucum extract against mouse leukemia cell line, L1210, grown as ascites in mouse model.
In vitro Results showed that S.
glaucum inhibited L1210 cancer cells proliferation and induced apoptosis and that the apoptotic activities.
The mechanism underlying cell death was due to induction of apoptosis, which was associated by DNA damage and morphological changes of the treated cells.
In vivo study indicated that S.
glaucum has ability to suppress cancer progression in treated animals.
These findings indicate that the S.
glaucum extract can be a candidate agent for fighting cancer), on mice (Swiss albino mice).
The antiproliferative and cytotoxic activities of the S.
glaucum were determined using the trypan blue dye exclusion and the WST-1 cell proliferation tests.
The underlying possible mechanism of cell death was investigated whether it is necrotic or apoptotic by single cell gel electrophoresis (comet assay) and dual acridine orange/ethidium bromide (AO/EB) staining.
The antitumor activity of the S.
glaucum extract against mouse leukemia cell line, L1210, grown as ascites in mouse model.
In vitro Results showed that S.
glaucum inhibited L1210 cancer cells proliferation and induced apoptosis and that the apoptotic activities.
The mechanism underlying cell death was due to induction of apoptosis, which was associated by DNA damage and morphological changes of the treated cells.
In vivo study indicated that S.
glaucum has ability to suppress cancer progression in treated animals.
These findings indicate that the S.
glaucum extract can be a candidate agent for fighting cance
American Psychological Association (APA)
al-Baqmi, Najah Muhammad Hamid& Abu Zinadah, Usamah Abd Allah& al-Asuli, Muhammad Zaki Mustafa& al-Matri, Muhammad Ali& Anwar, Yasir& al-Asuli, Sufyan Muhammad. 2017. Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro. Journal of King Abdulaziz University : Sciences،Vol. 29, no. 2, pp.31-47.
https://search.emarefa.net/detail/BIM-903031
Modern Language Association (MLA)
al-Baqmi, Najah Muhammad Hamid…[et al.]. Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro. Journal of King Abdulaziz University : Sciences Vol. 29, no. 2 (2017), pp.31-47.
https://search.emarefa.net/detail/BIM-903031
American Medical Association (AMA)
al-Baqmi, Najah Muhammad Hamid& Abu Zinadah, Usamah Abd Allah& al-Asuli, Muhammad Zaki Mustafa& al-Matri, Muhammad Ali& Anwar, Yasir& al-Asuli, Sufyan Muhammad. Assesment of anticarcinogenic activities of the soft coral sarcophyton glaucum extract on mouse leukemia in vivo and in vitro. Journal of King Abdulaziz University : Sciences. 2017. Vol. 29, no. 2, pp.31-47.
https://search.emarefa.net/detail/BIM-903031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 44-46
Record ID
BIM-903031