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Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds
المؤلفون المشاركون
المصدر
Journal of Natural Sciences, Life and Applied Sciences
العدد
المجلد 1، العدد 1 (31 مارس/آذار 2017)، ص ص. 30-40، 11ص.
الناشر
تاريخ النشر
2017-03-31
دولة النشر
فلسطين (قطاع غزة)
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This work describes the synthesis of novel nonracemic derivatives of imidazole.
Some oxidation reactions using Mn(II), Se(II) and nitric acid were employed for the synthesis of the starting materials, imidazolyl carboxaldehydes in straightforward steps.
These key step compounds were then subjected to schiff bases and reductive amination processes for the synthesis imidazolylimio and imidazolylamino compounds using standard conditions.
Attempts to purify some imidazolylamino compounds using kugelrohr distillation technique have been unsuccessful.
However, recrystallization from acetonitrile allowed isolation some compounds in good yields.
The new compounds that were synthesised were potential ligands for complexation of metals.
Ag(I) was used to synthesis of several metal complexes.
These compounds were characterised by nuclear magnetic resonance (NMR) and fourier transform infrared spectroscopy (FTIR) as well as elemental analysis method.
These imidazole derivatives have been screened for activity against Candida albicans.
Although the Senantiomer of N-[(1E)-1-benzyl imidazol-2-ylmethylene]-N′-(1-phenylethyl)amine was found inactive against C.
albicans, the R-enantiomer showed moderate activity.
However, in two instances the activity was greater than that for ketoconazole which is a common agent to cure candida infestation
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zayd, A. M.& Khalifah, M.. 2017. Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds. Journal of Natural Sciences, Life and Applied Sciences،Vol. 1, no. 1, pp.30-40.
https://search.emarefa.net/detail/BIM-904203
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zayd, A. M.& Khalifah, M.. Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds. Journal of Natural Sciences, Life and Applied Sciences Vol. 1, no. 1 (Mar. 2017), pp.30-40.
https://search.emarefa.net/detail/BIM-904203
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zayd, A. M.& Khalifah, M.. Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds. Journal of Natural Sciences, Life and Applied Sciences. 2017. Vol. 1, no. 1, pp.30-40.
https://search.emarefa.net/detail/BIM-904203
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 40
رقم السجل
BIM-904203
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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