Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds
Joint Authors
Source
Journal of Natural Sciences, Life and Applied Sciences
Issue
Vol. 1, Issue 1 (31 Mar. 2017), pp.30-40, 11 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Palestine (Gaza Strip)
No. of Pages
11
Main Subjects
Abstract EN
This work describes the synthesis of novel nonracemic derivatives of imidazole.
Some oxidation reactions using Mn(II), Se(II) and nitric acid were employed for the synthesis of the starting materials, imidazolyl carboxaldehydes in straightforward steps.
These key step compounds were then subjected to schiff bases and reductive amination processes for the synthesis imidazolylimio and imidazolylamino compounds using standard conditions.
Attempts to purify some imidazolylamino compounds using kugelrohr distillation technique have been unsuccessful.
However, recrystallization from acetonitrile allowed isolation some compounds in good yields.
The new compounds that were synthesised were potential ligands for complexation of metals.
Ag(I) was used to synthesis of several metal complexes.
These compounds were characterised by nuclear magnetic resonance (NMR) and fourier transform infrared spectroscopy (FTIR) as well as elemental analysis method.
These imidazole derivatives have been screened for activity against Candida albicans.
Although the Senantiomer of N-[(1E)-1-benzyl imidazol-2-ylmethylene]-N′-(1-phenylethyl)amine was found inactive against C.
albicans, the R-enantiomer showed moderate activity.
However, in two instances the activity was greater than that for ketoconazole which is a common agent to cure candida infestation
American Psychological Association (APA)
Zayd, A. M.& Khalifah, M.. 2017. Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds. Journal of Natural Sciences, Life and Applied Sciences،Vol. 1, no. 1, pp.30-40.
https://search.emarefa.net/detail/BIM-904203
Modern Language Association (MLA)
Zayd, A. M.& Khalifah, M.. Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds. Journal of Natural Sciences, Life and Applied Sciences Vol. 1, no. 1 (Mar. 2017), pp.30-40.
https://search.emarefa.net/detail/BIM-904203
American Medical Association (AMA)
Zayd, A. M.& Khalifah, M.. Synthesis of anti-fungals, from chiral imidazolyl-imino and amino compounds. Journal of Natural Sciences, Life and Applied Sciences. 2017. Vol. 1, no. 1, pp.30-40.
https://search.emarefa.net/detail/BIM-904203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 40
Record ID
BIM-904203