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Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults
المؤلفون المشاركون
Ogundele, Olusegun E.
Osinubi, Abraham A. A.
Awofala, Awoyemi A.
Adekoya, Khalid O.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 2 (30 إبريل/نيسان 2018)، ص ص. 123-127، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background: The association of obesity with adiponectin gene has been reported in different populations with various inconsistencies.
Data from Nigeria is very scanty on the association.
Aim: We investigated possible associations of adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPs) rs2241766 (+45T>G in exon 2), rs266729 (11377C>G in promoter) and rs1501299 (+276G>T in intron 2) with body mass index (BMI), waist circumference (WC) and hip circumference (HC), in our cross-sectional study.
Subjects and methods: SNPs in ADIPOQ were genotyped in 107 subjects (81 females, 26 males; mean age 22.2 years) by Sequenom MassARRAY.
Notably, rs2241766 was removed for not reaching Hardy-Weinberg equilibrium.
BMI was calculated (kg/m2 ) while WC and HC were measured using standard procedures Results: Linear regression showed that variant rs1501299 was not associated with BMI, WC or HC but rs266729 was associated with increased measures of obesity involving BMI (recessive model; beta coefficient [b], 12.85; 95% confidence interval [CI], 6.47, 19.24, codominant model; GG, b, 13.08; 95% CI, 6.71, 19.46, GC, b, 1.04; 95% CI, 0.60, 2.68 and log-additive model; b, 2.117; 95% CI, 0.55, 3.68), WC (recessive model; b, 22.17; 95% CI, 7.11, 37.23 and codominant model; GG, b, 21.857; 95% CI, 6.74, 36.98, GC, b, 1.459; 95% CI, 5.52.43) and HC (recessive model; b, 33.56; 95% CI, 15.41, 51.70, codominant model; GG, b, 34.171; 95% CI, 16.04, 52.30, GC, b, 2.771; 95% CI, and g-additive model; b, 5.466; 95% CI, 1.14, 9.80).
Conclusion: This study in young Nigerian adults confirmed previously reported association of SNP 377C>G with obesity measures in other populations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ogundele, Olusegun E.& Adekoya, Khalid O.& Osinubi, Abraham A. A.& Awofala, Awoyemi A.. 2018. Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 2, pp.123-127.
https://search.emarefa.net/detail/BIM-905783
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ogundele, Olusegun E.…[et al.]. Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 2 (Apr. 2018), pp.123-127.
https://search.emarefa.net/detail/BIM-905783
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ogundele, Olusegun E.& Adekoya, Khalid O.& Osinubi, Abraham A. A.& Awofala, Awoyemi A.. Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 2, pp.123-127.
https://search.emarefa.net/detail/BIM-905783
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 127
رقم السجل
BIM-905783
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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