Association of adiponectin gene (ADIPOQ)‎ polymorphisms with measures of obesity in Nigerian young adults

Abstract EN

Background: The association of obesity with adiponectin gene has been reported in different populations with various inconsistencies.

Data from Nigeria is very scanty on the association.

Aim: We investigated possible associations of adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPs) rs2241766 (+45T>G in exon 2), rs266729 (11377C>G in promoter) and rs1501299 (+276G>T in intron 2) with body mass index (BMI), waist circumference (WC) and hip circumference (HC), in our cross-sectional study.

Subjects and methods: SNPs in ADIPOQ were genotyped in 107 subjects (81 females, 26 males; mean age 22.2 years) by Sequenom MassARRAY.

Notably, rs2241766 was removed for not reaching Hardy-Weinberg equilibrium.

BMI was calculated (kg/m2 ) while WC and HC were measured using standard procedures Results: Linear regression showed that variant rs1501299 was not associated with BMI, WC or HC but rs266729 was associated with increased measures of obesity involving BMI (recessive model; beta coefficient [b], 12.85; 95% confidence interval [CI], 6.47, 19.24, codominant model; GG, b, 13.08; 95% CI, 6.71, 19.46, GC, b, 1.04; 95% CI, 0.60, 2.68 and log-additive model; b, 2.117; 95% CI, 0.55, 3.68), WC (recessive model; b, 22.17; 95% CI, 7.11, 37.23 and codominant model; GG, b, 21.857; 95% CI, 6.74, 36.98, GC, b, 1.459; 95% CI, 5.52.43) and HC (recessive model; b, 33.56; 95% CI, 15.41, 51.70, codominant model; GG, b, 34.171; 95% CI, 16.04, 52.30, GC, b, 2.771; 95% CI, and g-additive model; b, 5.466; 95% CI, 1.14, 9.80).

Conclusion: This study in young Nigerian adults confirmed previously reported association of SNP 377C>G with obesity measures in other populations.