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Protective role of the combination of resveratrol and N-acetylcysteine in preventing acute paracetamol-induced nephropathy in rats
العناوين الأخرى
الدور الوقائي لمزيج من الريسفيراترول و ن-أسيتيل سيستين لمنع اعتلال الكلى الحاد الناتج عن الباراسيتامول في الجرذان
المؤلف
المصدر
Scientific Journal of King Faisal University : Basic and Applied Sciences
العدد
المجلد 19، العدد 1 (30 يونيو/حزيران 2018)، ص ص. 39-55، 17ص.
الناشر
تاريخ النشر
2018-06-30
دولة النشر
السعودية
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
As an overdose of Paracetamol (PCM) is nephrotoxic, the present study aimed to investigate and compare the individual therapeutic effects of Resveratrol (RES), N-acetyl cysteine (NAC), and their combination against PCM induced nephrotoxicity in rats in addition to illustrate possible mechanisms of action.
Fifty adult Wistar rats were divided into 5 groups (n=10/group): 1) control group, 2) PCM group (1000 mg/kg b.wt), 3) PCM post-treated with RES (25 mg/kg b.wt), 4) PCM post-treated with NAC (1.2 g/kg b.wt), and 5) PCM post-treated with concomitant RES and NAC.
PCM was administered during the first 2 days and all other treatments were administered intraperitoneally daily for the post PCM induction five days.
At the end of the study, serum electrolytes, renal levels of oxidative stress marker, mRNA expression levels of ɣ-glutamyl cysteine ligase (ɣ-GCL), and Na+/K+ ATPase were measured.
PCM intoxication caused oxidative stress-induced renal damage as evident by the inhibition of mRNA expression of ɣ-GCL and glutathione (GSH) levels, and by the inhibition of the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST).
PCM induced renal damage was mediated by a parallel decrease in activity and expression levels of Na+/K+ ATPase.
However, while delayed NAC administration to post PCM intoxicated rat poorly improved these parameters and changes in kidney structure, the effect of RES was also partially but more profound.
On the other hand, concomitant administration of both NAC and RES completely reversed the alterations of serum electrolytes, renal architectures histological parameters, serum electrolytes, oxidative stress parameters, renal architectures histological parameters, and resulted in normal renal mRNA expression of both ɣ-GCL and Na+/K+ ATPase.
These data suggest that NAC and RES act in a synergistic manner and completely ameliorate PCM induced nephrotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shati. Ali A.. 2018. Protective role of the combination of resveratrol and N-acetylcysteine in preventing acute paracetamol-induced nephropathy in rats. Scientific Journal of King Faisal University : Basic and Applied Sciences،Vol. 19, no. 1, pp.39-55.
https://search.emarefa.net/detail/BIM-908329
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shati. Ali A.. Protective role of the combination of resveratrol and N-acetylcysteine in preventing acute paracetamol-induced nephropathy in rats. Scientific Journal of King Faisal University : Basic and Applied Sciences Vol. 19, no. 1 (Jun. 2018), pp.39-55.
https://search.emarefa.net/detail/BIM-908329
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shati. Ali A.. Protective role of the combination of resveratrol and N-acetylcysteine in preventing acute paracetamol-induced nephropathy in rats. Scientific Journal of King Faisal University : Basic and Applied Sciences. 2018. Vol. 19, no. 1, pp.39-55.
https://search.emarefa.net/detail/BIM-908329
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
رقم السجل
BIM-908329
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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