Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats

المؤلف

Ren, Lei

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 26، العدد 8 (31 ديسمبر/كانون الأول 2019)، ص ص. 1961-1972، 12ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2019-12-31

دولة النشر

السعودية

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Diabetes mellitus (DM) is a metabolic disorder with numerous symptoms categorized via serves hyperglycemia effect along with altered fat, protein and carbohydrate metabolism mainly resultant from defects in insulin action/secretion or both.

The aim of the current experimental study was to comfort the neuroprotective effect of ganoderic acid against the streptozotocin (STZ)-induced type I diabetes mellitus in mice and explore the underlying mechanism.

Differentiation of 3T3-L1 preadipocytes effect; hepatic and glucose consumption effect of ganoderic acid was estimated on HepG2 cell lines and peroxisome proliferator-activated receptor (PPAR).

FFA content was estimated in adipose and hepatic tissues.

Ganoderic acid induced the 3T3-L1 preadipocytes differentiation.

The mRNA expression of PPAR was increased in the high glucose-treated group in HepG2 and ganoderic acid treatment down-regulated the mRNA expression of PPAR.

Ganoderic acid exhibited the inhibitory effect of a-glucosidase and aamylase.

Ganoderic acid demonstrated the reduced blood glucose and increase insulin level and also reduced the free fatty in hepatic and adipose tissue.

Histopathological study showed the enhancement of b-cells in ganoderic acid-treated mice.

Finally, their prebiotic effects on gut microbiota were illustrated via enhancing the population of diabetes resistant bacteria and also reducing the quantity of diabetes sensitive bacteria.

Ganoderic acid attenuated STZ induced T1DM in mice via inflammatory pathways.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ren, Lei. 2019. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ren, Lei. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ren, Lei. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 1971-1972

رقم السجل

BIM-910112