Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats
المؤلف
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 8 (31 ديسمبر/كانون الأول 2019)، ص ص. 1961-1972، 12ص.
الناشر
تاريخ النشر
2019-12-31
دولة النشر
السعودية
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Diabetes mellitus (DM) is a metabolic disorder with numerous symptoms categorized via serves hyperglycemia effect along with altered fat, protein and carbohydrate metabolism mainly resultant from defects in insulin action/secretion or both.
The aim of the current experimental study was to comfort the neuroprotective effect of ganoderic acid against the streptozotocin (STZ)-induced type I diabetes mellitus in mice and explore the underlying mechanism.
Differentiation of 3T3-L1 preadipocytes effect; hepatic and glucose consumption effect of ganoderic acid was estimated on HepG2 cell lines and peroxisome proliferator-activated receptor (PPAR).
FFA content was estimated in adipose and hepatic tissues.
Ganoderic acid induced the 3T3-L1 preadipocytes differentiation.
The mRNA expression of PPAR was increased in the high glucose-treated group in HepG2 and ganoderic acid treatment down-regulated the mRNA expression of PPAR.
Ganoderic acid exhibited the inhibitory effect of a-glucosidase and aamylase.
Ganoderic acid demonstrated the reduced blood glucose and increase insulin level and also reduced the free fatty in hepatic and adipose tissue.
Histopathological study showed the enhancement of b-cells in ganoderic acid-treated mice.
Finally, their prebiotic effects on gut microbiota were illustrated via enhancing the population of diabetes resistant bacteria and also reducing the quantity of diabetes sensitive bacteria.
Ganoderic acid attenuated STZ induced T1DM in mice via inflammatory pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Lei. 2019. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Lei. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Lei. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1971-1972
رقم السجل
BIM-910112
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر