Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats

Author

Ren, Lei

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.1961-1972, 12 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

12

Main Topic

Diseases

Topics

Abstract EN

Diabetes mellitus (DM) is a metabolic disorder with numerous symptoms categorized via serves hyperglycemia effect along with altered fat, protein and carbohydrate metabolism mainly resultant from defects in insulin action/secretion or both.

The aim of the current experimental study was to comfort the neuroprotective effect of ganoderic acid against the streptozotocin (STZ)-induced type I diabetes mellitus in mice and explore the underlying mechanism.

Differentiation of 3T3-L1 preadipocytes effect; hepatic and glucose consumption effect of ganoderic acid was estimated on HepG2 cell lines and peroxisome proliferator-activated receptor (PPAR).

FFA content was estimated in adipose and hepatic tissues.

Ganoderic acid induced the 3T3-L1 preadipocytes differentiation.

The mRNA expression of PPAR was increased in the high glucose-treated group in HepG2 and ganoderic acid treatment down-regulated the mRNA expression of PPAR.

Ganoderic acid exhibited the inhibitory effect of a-glucosidase and aamylase.

Ganoderic acid demonstrated the reduced blood glucose and increase insulin level and also reduced the free fatty in hepatic and adipose tissue.

Histopathological study showed the enhancement of b-cells in ganoderic acid-treated mice.

Finally, their prebiotic effects on gut microbiota were illustrated via enhancing the population of diabetes resistant bacteria and also reducing the quantity of diabetes sensitive bacteria.

Ganoderic acid attenuated STZ induced T1DM in mice via inflammatory pathways.

American Psychological Association (APA)

Ren, Lei. 2019. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112

Modern Language Association (MLA)

Ren, Lei. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112

American Medical Association (AMA)

Ren, Lei. Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.1961-1972.
https://search.emarefa.net/detail/BIM-910112

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1971-1972

Record ID

BIM-910112