The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model
المؤلفون المشاركون
Chaudhuri, Tapas Kumar
Kar, Pallab
Dutta, Somit
Roy, Ayan
Chakraborty, Arnab Kumar
Sen, Subhajit
Kumar, Anoop
Sen, Arnab
Lee, Joongku
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 26، العدد 7 (30 نوفمبر/تشرين الثاني 2019)، ص ص. 1539-1547، 9ص.
الناشر
تاريخ النشر
2019-11-30
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Clerodendrum is a plant with potent antioxidant activity and has been frequently employed as a traditional remedy against bronchitis, asthma, liver and stomach disorders.
Three species of genus Clerodendrum namely Clerodendrum indicum, C.
colebrookianum and C.
inerme (Syn.
Volkameria inermis) were investigated for their possible activity against oxidative stress induced liver injury.
Apart from generation of Reactive Oxygen Species (ROS) in the WRL-68 cell line (human hepatic cell line), in-vitro and in-vivo antioxidant assays were also assessed.
Features of immune cell proliferation (MTT) were analyzed thoroughly.
Gas Chromatography-Mass Spectrometry (GC–MS) and Fourier Transform Infrared Spectroscopy (FTIR) analyses have been performed to identify the active biological compounds.
These active biological compounds were further subjected to molecular docking.
The antioxidant activity of three Clerodendrum sp.
was significantly high in DPPH, nitric oxide, hydroxyl radical and hydrogen peroxide etc.
Biochemical parameters like catalase, superoxide dismutase (SOD) and reduced glutathione (GSH) were generated in excess due to CCl4 administration, which was ameliorated by treating with Clerodendrum extract.
The phytochemical 24,25-Dihydroxyvitamin D shows excellent binding affinity in Autodock Vina.
The present study provided convincing evidences that C.
indicum and C.
inerme showed good result but C.
colebrookianum performed better by almost all means.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kar, Pallab& Dutta, Somit& Chakraborty, Arnab Kumar& Roy, Ayan& Sen, Subhajit& Kumar, Anoop…[et al.]. 2019. The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1539-1547.
https://search.emarefa.net/detail/BIM-910170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kar, Pallab…[et al.]. The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1539-1547.
https://search.emarefa.net/detail/BIM-910170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kar, Pallab& Dutta, Somit& Chakraborty, Arnab Kumar& Roy, Ayan& Sen, Subhajit& Kumar, Anoop…[et al.]. The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1539-1547.
https://search.emarefa.net/detail/BIM-910170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1547
رقم السجل
BIM-910170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر