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The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model
Joint Authors
Chaudhuri, Tapas Kumar
Kar, Pallab
Dutta, Somit
Roy, Ayan
Chakraborty, Arnab Kumar
Sen, Subhajit
Kumar, Anoop
Sen, Arnab
Lee, Joongku
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1539-1547, 9 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Clerodendrum is a plant with potent antioxidant activity and has been frequently employed as a traditional remedy against bronchitis, asthma, liver and stomach disorders.
Three species of genus Clerodendrum namely Clerodendrum indicum, C.
colebrookianum and C.
inerme (Syn.
Volkameria inermis) were investigated for their possible activity against oxidative stress induced liver injury.
Apart from generation of Reactive Oxygen Species (ROS) in the WRL-68 cell line (human hepatic cell line), in-vitro and in-vivo antioxidant assays were also assessed.
Features of immune cell proliferation (MTT) were analyzed thoroughly.
Gas Chromatography-Mass Spectrometry (GC–MS) and Fourier Transform Infrared Spectroscopy (FTIR) analyses have been performed to identify the active biological compounds.
These active biological compounds were further subjected to molecular docking.
The antioxidant activity of three Clerodendrum sp.
was significantly high in DPPH, nitric oxide, hydroxyl radical and hydrogen peroxide etc.
Biochemical parameters like catalase, superoxide dismutase (SOD) and reduced glutathione (GSH) were generated in excess due to CCl4 administration, which was ameliorated by treating with Clerodendrum extract.
The phytochemical 24,25-Dihydroxyvitamin D shows excellent binding affinity in Autodock Vina.
The present study provided convincing evidences that C.
indicum and C.
inerme showed good result but C.
colebrookianum performed better by almost all means.
American Psychological Association (APA)
Kar, Pallab& Dutta, Somit& Chakraborty, Arnab Kumar& Roy, Ayan& Sen, Subhajit& Kumar, Anoop…[et al.]. 2019. The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1539-1547.
https://search.emarefa.net/detail/BIM-910170
Modern Language Association (MLA)
Kar, Pallab…[et al.]. The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1539-1547.
https://search.emarefa.net/detail/BIM-910170
American Medical Association (AMA)
Kar, Pallab& Dutta, Somit& Chakraborty, Arnab Kumar& Roy, Ayan& Sen, Subhajit& Kumar, Anoop…[et al.]. The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1539-1547.
https://search.emarefa.net/detail/BIM-910170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1547
Record ID
BIM-910170