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Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study
المؤلفون المشاركون
Pourmasumi, Suhaylah
Qasimi, Nisrin
Talibi, Ali Rida
Zadah, Jalal Qasim
Sabeti, Parvin
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 21، العدد 11 (30 نوفمبر/تشرين الثاني 2019)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2019-11-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
- الإجهاض
- المرضى
- الطفرة
- الضرر
- فيتامين ي
- الأحماض النووية
- السيلينيوم
- الزنك
- دي أن آي
- الجوانب الوراثية
- مضادات الأكسدة
- الحيوانات المنوية
- الأكسجين النشط
الملخص EN
Background: Recurrent Pregnancy Loss (RPL) is an important medical problem comprising approximately 15% of all pregnancies.
Sperm DNA damage and level of seminal ROS may have a role in RPL.
Objectives: The main aim of the present study was to appraise the efficacy of antioxidants for improving these parameters in RPL patients.
Methods: In a clinical trial, 90 couples suffering from RPL were divided into two groups from April 2014 to December 2015 at the Yazd Research and Clinical Center for Infertility in Iran.
Group I received supplemental vitamin E (400 g) daily in combination with Se (200 g) and the other group received vitamin E plus zinc for three months.
Sperm parameters, sperm DNA damage, and seminal ROS were evaluated before and after treatment and compared between the two groups.
Data were analyzed by SPSS and P values of 0.05 were considered statistically significant.
Results: Our results revealed normal sperm parameters in RPL patients.
Sperm parameters substantially improved in the two treated groups (P 0.05).
The ROS level dramatically reduced in the two groups (P = 0.01).
The evaluation of chromatin integrity with AB staining did not show any remarkable changes in group 1 (P = 0.3), but it showed a considerable rate reduction in group 2 (P = 0.04).
Also, it showed significant decreases with TB, CMA3, and TUNEL assays in both groups (P = 0.001).
However, we did not find any significant difference between the two groups.
Conclusions: Supplemental vitamin E in combination with selenium or zinc may improve semen quality by decreasing the level of seminal ROS and sperm DNA damage in RPL patients.
We advocate their use for improving the quality of the men’s sperm DNA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pourmasumi, Suhaylah& Qasimi, Nisrin& Talibi, Ali Rida& Zadah, Jalal Qasim& Sabeti, Parvin. 2019. Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study. Iranian Red Crescent Medical Journal،Vol. 21, no. 11, pp.1-8.
https://search.emarefa.net/detail/BIM-910618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pourmasumi, Suhaylah…[et al.]. Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study. Iranian Red Crescent Medical Journal Vol. 21, no. 11 (Nov. 2019), pp.1-8.
https://search.emarefa.net/detail/BIM-910618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pourmasumi, Suhaylah& Qasimi, Nisrin& Talibi, Ali Rida& Zadah, Jalal Qasim& Sabeti, Parvin. Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 11, pp.1-8.
https://search.emarefa.net/detail/BIM-910618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English ; abstracts in .
رقم السجل
BIM-910618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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