Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study
Joint Authors
Pourmasumi, Suhaylah
Qasimi, Nisrin
Talibi, Ali Rida
Zadah, Jalal Qasim
Sabeti, Parvin
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 21, Issue 11 (30 Nov. 2019), pp.1-8, 8 p.
Publisher
Publication Date
2019-11-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
- Abortion
- Patients
- Mutation
- Damages
- Vitamin E
- Nucleic acids
- Selenium
- Zinc
- DNA
- Genetic aspects
- Antioxidants
- Sperm
- Active oxygen
Abstract EN
Background: Recurrent Pregnancy Loss (RPL) is an important medical problem comprising approximately 15% of all pregnancies.
Sperm DNA damage and level of seminal ROS may have a role in RPL.
Objectives: The main aim of the present study was to appraise the efficacy of antioxidants for improving these parameters in RPL patients.
Methods: In a clinical trial, 90 couples suffering from RPL were divided into two groups from April 2014 to December 2015 at the Yazd Research and Clinical Center for Infertility in Iran.
Group I received supplemental vitamin E (400 g) daily in combination with Se (200 g) and the other group received vitamin E plus zinc for three months.
Sperm parameters, sperm DNA damage, and seminal ROS were evaluated before and after treatment and compared between the two groups.
Data were analyzed by SPSS and P values of 0.05 were considered statistically significant.
Results: Our results revealed normal sperm parameters in RPL patients.
Sperm parameters substantially improved in the two treated groups (P 0.05).
The ROS level dramatically reduced in the two groups (P = 0.01).
The evaluation of chromatin integrity with AB staining did not show any remarkable changes in group 1 (P = 0.3), but it showed a considerable rate reduction in group 2 (P = 0.04).
Also, it showed significant decreases with TB, CMA3, and TUNEL assays in both groups (P = 0.001).
However, we did not find any significant difference between the two groups.
Conclusions: Supplemental vitamin E in combination with selenium or zinc may improve semen quality by decreasing the level of seminal ROS and sperm DNA damage in RPL patients.
We advocate their use for improving the quality of the men’s sperm DNA.
American Psychological Association (APA)
Pourmasumi, Suhaylah& Qasimi, Nisrin& Talibi, Ali Rida& Zadah, Jalal Qasim& Sabeti, Parvin. 2019. Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study. Iranian Red Crescent Medical Journal،Vol. 21, no. 11, pp.1-8.
https://search.emarefa.net/detail/BIM-910618
Modern Language Association (MLA)
Pourmasumi, Suhaylah…[et al.]. Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study. Iranian Red Crescent Medical Journal Vol. 21, no. 11 (Nov. 2019), pp.1-8.
https://search.emarefa.net/detail/BIM-910618
American Medical Association (AMA)
Pourmasumi, Suhaylah& Qasimi, Nisrin& Talibi, Ali Rida& Zadah, Jalal Qasim& Sabeti, Parvin. Protective effects of antioxidant supplements on sperm parameters, sperm DNA damage and level of seminal ROS in RPL patients : a clinical trial study. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 11, pp.1-8.
https://search.emarefa.net/detail/BIM-910618
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in .
Record ID
BIM-910618