Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits
العناوين الأخرى
دراسة التأثير النسيجي و الجيني لعقار الترامادول على الأعضاء (الدماغ و الكبد و الكلية) في الأرانب البالغة
المؤلف
Abd Allah, Buthaynah Abd al-Hamid
المصدر
The Iraqi Journal of Agricultural Science
العدد
المجلد 49، العدد 6 (31 ديسمبر/كانون الأول 2018)، ص ص. 1083-1089، 7ص.
الناشر
تاريخ النشر
2018-12-31
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
This study was to examine the histological changes in liver and kidney in tramadol -induced rabbits .
This study was conducted on 10 adult male rabbits.
Rabbits.
were divided evenly into two groups: control group, received 1 ml normal saline 0.9% Treated group received 0.3 ml of tramadol subcutaneously for 30 days.
Results: The histological analysis of the liver showed that the thickening wall with minimal fibrosis in the periportal area infiltration of inflammatory cells in necrotic change of the hepatocytes massive vacuolation of the hepatocyte, kupffer cell were present intensity in the sinusoid.
The histopathological examination of kidney revealed lymphocyte infiltration , congestion ,glomerulus and tubular damage.
The tubular was containing hypertrophied epithelial cell which block the lumen .Brain tissues in treated groups showed degeneration of pyramidal cells in the cortex , congestion of the blood vessels in the cortex and medulla.
The cortex certain pyramidal cell with slight enlarged.
The random amplified polymorphic DNA (RAPD) based on Polymerase Chain Reaction (PCR) with 5 primers were applied, used to estimate fingerprinting and Genetic Distance for 3organs .
the results showed clear difference in the number of packets as well as in the genetic dimension compared to the control group.
Conclusion: The histopathological and molecular alterations of liver, kidney and brain tissues threw lights on the possible risks of increased hepatic, renal and neurological damages evoked by repeated administration of tramadol for long periods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd Allah, Buthaynah Abd al-Hamid. 2018. Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits. The Iraqi Journal of Agricultural Science،Vol. 49, no. 6, pp.1083-1089.
https://search.emarefa.net/detail/BIM-910847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd Allah, Buthaynah Abd al-Hamid. Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits. The Iraqi Journal of Agricultural Science Vol. 49, no. 6 (2018), pp.1083-1089.
https://search.emarefa.net/detail/BIM-910847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd Allah, Buthaynah Abd al-Hamid. Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits. The Iraqi Journal of Agricultural Science. 2018. Vol. 49, no. 6, pp.1083-1089.
https://search.emarefa.net/detail/BIM-910847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1089
رقم السجل
BIM-910847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر